Millipore Sigma Vibrant Logo

MABF1489 Anti-CD161 (NK1.1) (mouse), FITC, clone PK136 Antibody

View Products on Sigmaaldrich.com
MABF1489
25 μg  
Preis wird abgerufen...
Preis nicht abrufbar
Die Mindestmenge muss ein Vielfaches sein von
Maximum Quantity is
Bei Bestätigung Weitere Informationen
Sie haben () gespart
 
Bitte erfragen
Eingeschränkte Verfügbarkeit
Eingeschränkte Verfügbarkeit
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

      Sonderaktionen

       

      Kontakt zum Kundenservice

      Übersicht

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFCMFITCMonoclonal Antibody
      Description
      Catalogue NumberMABF1489
      DescriptionAnti-CD161 (NK1.1) (mouse), FITC, clone PK136 Antibody
      Alternate Names
      • Killer cell lectin-like receptor subfamily B member 1B allele A
      • CD161 antigen-like family member B
      • Lymphocyte antigen 55b (Ly-55b)
      • NKR-P1 34
      • Natural killer cell surface protein NKR-P1B allele SJL/BALB (NKR-P1B)
      • CD161b
      • CD161 (NK1.1)
      Background InformationThe PK136 antibody is specific for mouse NK1.1, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. NK1.1 is prominently expressed on natural killer (NK) cells, and is correlated with NK cytotoxic effects toward virus-infected cells and tumor cells. NK1.1 is expressed on subsets of NKT cells in certain mouse strains (C57BL/6, FVB/N, and NZB), yet absent from others (AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129). Putative subsets of NK cells and their expression of NK1.1 antigen are of continuing interest, including NK1.1+/CD117+ (c-Kit) cells reported to be immunosuppressive for CD8+ T cells in a mechanism involving PD-1 and PD-L1 (Ehlers et al. 2012. Endocrinology. 10: 1247).The PK136 antibody may be used for detection of NK1.1 expression on mouse strains including CE, B6, NZB, C58, Ma/My, ST, SJL, and FVB. The antibody is reported to react with an epitope common to NKR-P1B and NKR-P1C alloantigenic forms of NK1.1 (Carlyle et al. 2006. J. Immunol. 176: 7511-7524).
      References
      Product Information
      FormatFITC
      PresentationPurified Mouse monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
      Quality LevelMQ100
      Applications
      ApplicationThis mouse monoclonal Anti-CD161 (NK1.1) (mouse), FITC, clone PK136, Cat. No. MABF1489 is validated for use in Flow Cytometry, for the detection of CD161 (NK1.1).
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenImmunogen information for this antibody is proprietary information.
      ClonePK136
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • Klrb1b
      • Ly55b
      • Nkrp1b
      Purification MethodPurified by size-exclusion chromatography
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceThis monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

      Flow Cytometry Analysis: 0.5 μg from a representative lot detected CD161 (NK1.1) in one million C57Bl/6 splenocytes.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABF1489 04055977293098

      Verwandte Produkte & Anwendungen

      Related Products

      Bestellnummer Beschreibung  
      MABF1487 Anti- CD161 (NK1.1) (mouse), APC, clone PK136 Antibody Preis & Verfügbarkeit
      MABF1488 Anti- CD161 (NK1.1) (mouse), APC, clone PK136 Antibody Preis & Verfügbarkeit
      MABF1493 Anti- CD161 (NK1.1) (mouse), PerCP-Cy5.5, clone PK136 Antibody Preis & Verfügbarkeit
      MABF1496 Anti- CD161 (NK1.1) (mouse), redFluor™ 710, clone PK136 Antibody Preis & Verfügbarkeit
      MABF1497 Anti- CD161 (NK1.1) (mouse), redFluor™ 710, clone PK136 Antibody Preis & Verfügbarkeit

      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies