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MABN1837 Anti-AGE Antibody, Carboxy-Methyl Lysine Antibody, clone 6C7

Anti-AGE, Carboxy-Methyl Lysine, clone 6C7, Cat. No. MABN1837, is a highly specific mouse monoclonal antibody, that targets Carboxy-Methyl Lysine (CML) modified proteins and has been tested in Immunohistochemistry (Paraffin).

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Research Category: Neuroscience
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MABN1837
100 μg  
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      Übersicht

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MIH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN1837
      DescriptionAnti-AGE Antibody, Carboxy-Methyl Lysine Antibody, clone 6C7
      Alternate Names
      • N(epsilon)-(carboxymethyl) lysine
      • CML
      • AGE-CML
      • N-epsilon-CML
      • AGE-CML (6C7) Antibody
      Background InformationChronic accumulation of Advanced Glycation End products (AGEs) is a common feature during aging, hyperlipidemia, and diabetes and affects function of proteins, lipids, and DNA. Although formation of AGE products is considered to be predominantly an endogenous process, certain external factors, such as some dietary products and smoking can increase the level of AGE in tissues. Under certain conditions glucose may form covalent adducts with the plasma proteins through the process of glycation. Glycation is a non-enzymatic reaction of reducing carbohydrates with lysine side chains and N-terminal amino groups of proteins. The term AGE often refers to non-reactive terminal products, such as N- carboxymethyllysine (CML) as well as reactive precursors, such as methylglyoxal (MG). CML is an AGE product that is usually found on proteins and lipids as a result of oxidative stress and chemical glycation. Excessive glycation can disrupt protein function by altering enzyme activity, receptor function, and molecular conformation. Protein glycation and subsequent formation of AGE products contributes to the pathogenesis of diabetes-related complications, such as retinopathy, nephropathy, and neuropathy. Higher levels of CML have been linked to greater hip fracture risk in older adults, independent of bone mineral density. AGE products interact with a variety of cell-surface AGE-binding receptors (RAGE) that results in their endocytosis and degradation. It can also generate pro-oxidant and pro-inflammatory events in cells. AGE products could also contribute to the development or worsening of many degenerative diseases, including Alzheimer's disease. (Ref.: Cai, W., et al. (2002). Mol. Med 8 (7): 337-346; Barzilay, JI et al (2014). J. Bone Miner. Res. 29(5):1061-1066).
      References
      Product Information
      FormatPurified
      HS Code3002 15 90
      PresentationPurified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-AGE, Carboxy-Methyl Lysine, clone 6C7, Cat. No. MABN1837, is a highly specific mouse monoclonal antibody, that targets Carboxy-Methyl Lysine (CML) modified proteins and has been tested in Immunohistochemistry (Paraffin).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenCarboxymethyl Lysine ­modified Keyhole Limpet Hemocyanin (KLH).
      Clone6C7
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 6C7 specifically reacts with carboxymethyl lysine modified proteins.
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse. Predicted to react with Human and Rat.
      Antibody TypeMonoclonal Antibody
      Purification MethodProtein G purified
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in mouse kidney tissue.

      Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected AGE, Carboxy-Methyl Lysine in kidney tissue of mice fed high AGE diets.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABN1837 04054839179020