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MABE881 Anti-26S proteasome regulatory subunit RPN11, clone 7C7.1 Antibody

This Anti-26S proteasome regulatory subunit RPN11, clone 7C7.1 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of 26S proteasome regulatory subunit RPN11.

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Research Category: Epigenetics & Nuclear Function, Epigenetics & Nuclear Function Research Sub-Category: Chromatin Biology, Cell Cycle, DNA Replication & Repair Gene Symbol: PSMD14, POH1 UniProt Number: O00487
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MABE881
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE881
      DescriptionAnti-26S proteasome regulatory subunit RPN11, clone 7C7.1 Antibody
      Alternate Names
      • 26S proteasome regulatory subunit RPN11
      • 26S proteasome-associated PAD1 homolog 1
      • 26S proteasome non-ATPase regulatory subunit 14
      Background Information26S proteasome non-ATPase regulatory subunit 14 is also known as 26S proteasome regulatory subunit RPN11 or 26S proteasome-associated PAD1 homolog 1. This protein is expressed from the PSMD14 gene and is the metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. 26S proteasome non-ATPase regulatory subunit 14 has a role in the response to double-strand breaks (DSBs) by regulating non-homologous end joining (NHEJ) via cleaving 'Lys-63'-linked polyubiquitin, retaining JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. 26S proteasome non-ATPase regulatory subunit 14 is also involved in homologous recombination repair by promoting RAD51 loading. 26S proteasome non-ATPase regulatory subunit 14 is widely expressed, but found in the highest levels in heart and skeletal muscle.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2bκ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-26S proteasome regulatory subunit RPN11, clone 7C7.1 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of 26S proteasome regulatory subunit RPN11.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected 26S proteasome regulatory subunit RPN11 in human cardiac myocytes and rat skelatal muscle myocytes.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 26S proteasome regulatory subunit RPN11.
      EpitopeRegion near N-terminus
      Clone7C7.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityRecognizes 26S proteasome regulatory subunit RPN11
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PSMD14
      • POH1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~ 35 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HT-1080 cell lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected 26S proteasome regulatory subunit RPN1 in 10 µg of HT-1080 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABE881 04053252986529