123871 Sigma-AldrichAkt Activator II, SC79 - CAS 305834-79-1 - Calbiochem
Akt Activator II, SC79, CAS 305834-79-1, is a cell-permeable compound that interacts with Akt PH domain PIP3 binding pocket and makes it more susceptible to phosphorylation by upstream Kinases.
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Synonyme: Ethyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
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Übersicht
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Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 123871-25MG |
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Glasflasche | 25 mg |
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| Description | |
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| Overview | A cell-permeable and blood-brain barrier permeant HA14-1 (Cat. No. 371971) analog that interacts with Akt PH domain PtdIns(3,4,5)P3- (PIP3) binding pocket, rendering Akt in a conformation susceptible to phosphorylation by upstream kinases. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473; 2 to 4 µg/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4 µg/ml) in vitro and in a murine MCAO model (40 mg/kg, i.p.) in vivo. |
| Catalogue Number | 123871 |
| Brand Family | Calbiochem® |
| Synonyms | Ethyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate |
| References | |
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| References | Jo. H., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 10581. |
| Product Information | |
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| CAS number | 305834-79-1 |
| Form | Off-white solid |
| Hill Formula | C₁₇H₁₇ClN₂O₅ |
| Chemical formula | C₁₇H₁₇ClN₂O₅ |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Primary Target | Pleckstrin homology (PH) domain of Akt |
| Purity | ≥98% by HPLC (sum of two isomers) |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 123871-25MG | 04055977206319 |
Documentation
Akt Activator II, SC79 - CAS 305834-79-1 - Calbiochem SDB
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Akt Activator II, SC79 - CAS 305834-79-1 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 123871 |
Literatur
| Übersicht |
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| Jo. H., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 10581. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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