Millipore Sigma Vibrant Logo

658395 AG 18 - CAS 118409-57-7 - Calbiochem

A broad-spectrum protein tyrosine kinase inhibitor.

AG 18 - CAS 118409-57-7 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: α-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810

Primary Target: epidermal growth factor receptor autophosphorylation
View Products on Sigmaaldrich.com
658395
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
118409-57-7C₁₀H₆N₂O₂

Preis & Verfügbarkeit

Bestellnummer VerfügbarkeitVerpackung St./Pkg. Preis Menge
658395-5MG
Verfügbarkeit wird abgerufen...
—
Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

      		 Kst.-Ampulle 5 mg
      Preis wird abgerufen...
      Preis nicht abrufbar
      Die Mindestmenge muss ein Vielfaches sein von
      Maximum Quantity is
      Bei Bestätigung Weitere Informationen
      Sie haben () gespart
       
      —
      Bitte erfragen
      		 —
      Description
      OverviewA broad-spectrum protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC50 = 40 µM) and the GTPase activity of transducin (IC50 = 10 µM). Inhibits aldosterone secretion in response to Angiotensin II (Cat. No. 05-23-0101). Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini.
      Catalogue Number658395
      Brand Family Calbiochem®
      Synonymsα-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810
      References
      ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
      Kapas, S., et al. 1995. Biochem. J. 305, 433.
      Seger, R., et al. 1995. J. Biol. Chem. 270, 28325.
      Williams, J.A. 1994. Am. J. Physiol. 267, G401.
      Geissler, J.F., et al. 1990. J. Biol. Chem. 265, 22255.
      Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
      Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
      Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.
      Product Information
      CAS number118409-57-7
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₀H₆N₂O₂
      Chemical formulaC₁₀H₆N₂O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetepidermal growth factor receptor autophosphorylation
      Primary Target IC<sub>50</sub>40 µM against epidermal growth factor receptor autophosphorylation; 10 µM against GTPase activity of transducin
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      658395-5MG 04055977261547

      Documentation

      AG 18 - CAS 118409-57-7 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      AG 18 - CAS 118409-57-7 - Calbiochem Analysenzertifikate

      TitelChargennummer
      658395

      Literatur

      Übersicht
      Jaleel, M., et al. 2004. Biochemistry 43, 8247.
      Kapas, S., et al. 1995. Biochem. J. 305, 433.
      Seger, R., et al. 1995. J. Biol. Chem. 270, 28325.
      Williams, J.A. 1994. Am. J. Physiol. 267, G401.
      Geissler, J.F., et al. 1990. J. Biol. Chem. 265, 22255.
      Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
      Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
      Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-May-2011 RFH
      Synonymsα-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810
      DescriptionA cell-permeable, reversible, substrate competitive protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC50 = 40 µM) and the GTPase activity of transducin (IC50 = 10 µM). Inhibits aldosterone secretion in response to angiotensin II. Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini. Also reported to inhibit guanylyl cyclase.
      FormYellow solid
      CAS number118409-57-7
      Chemical formulaC₁₀H₆N₂O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityAcetic acid, DMSO (100 mg/ml), or ethanol (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
      Kapas, S., et al. 1995. Biochem. J. 305, 433.
      Seger, R., et al. 1995. J. Biol. Chem. 270, 28325.
      Williams, J.A. 1994. Am. J. Physiol. 267, G401.
      Geissler, J.F., et al. 1990. J. Biol. Chem. 265, 22255.
      Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
      Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
      Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.