203390 Sigma-Aldrich(±)-Blebbistatin - CAS 674289-55-5 - Calbiochem
(±)-Blebbistatin, CAS 674289-55-5, is a cell-permeable, selective, and reversible inhibitor of nonmuscle myosin II. Blocks cell blebbing and disrupts cell migration & cytoKinesis in vertebrate cells.
More>> (±)-Blebbistatin, CAS 674289-55-5, is a cell-permeable, selective, and reversible inhibitor of nonmuscle myosin II. Blocks cell blebbing and disrupts cell migration & cytoKinesis in vertebrate cells. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 674289-55-5 | C₁₈H₁₆N₂O₂ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 203390-5MG |
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Kst.-Ampulle | 5 mg |
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| Description | |
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| Overview | A cell-permeable compound that acts as a selective, potent, and reversible inhibitor of nonmuscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤ 100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly. A 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203389) in 90% DMSO is also available. |
| Catalogue Number | 203390 |
| Brand Family | Calbiochem® |
| Product Information | |
|---|---|
| CAS number | 674289-55-5 |
| ATP Competitive | N |
| Form | Yellow solid |
| Hill Formula | C₁₈H₁₆N₂O₂ |
| Chemical formula | C₁₈H₁₆N₂O₂ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | ATPase |
| Primary Target IC<sub>50</sub> | <100 µM inhibiting the ATPase and gliding motility of human platelets |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 203390-5MG | 04055977221268 |
Documentation
(±)-Blebbistatin - CAS 674289-55-5 - Calbiochem SDB
| Titel |
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(±)-Blebbistatin - CAS 674289-55-5 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
|---|---|
| 203390 |
Literatur
| Übersicht |
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| Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472. Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557. Straight, A.F., et al. 2003. Science 299, 1743. Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a. |