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554412 Tetrodotoxin, Citrate, Fugu sp. - CAS 4368-28-9 - Calbiochem

Tetrodotoxin, Fugu sp., CAS 18660-81-6, is a reversible blocker of Na+ channels. Inhibits the release of glutamate via Na+-dependent glutamate transporter.

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Sinônimos: TTx

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      Description
      OverviewReversibly blocks Na+ channels, which are essential for the propagation of impulses in excitable membranes. Useful as a marker of Na+ channels in excitable tissues. Inhibits the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca2+ accumulation (IC50 = 63 nM).
      Catalogue Number554412
      Brand Family Calbiochem®
      SynonymsTTx
      References
      ReferencesLysko, P.G., et al. 1994. Stroke 25, 2476.
      Hu, S.L. and Kao, C.Y. 1985. Toxicon 23, 723.
      Nakamura, M. and Yasumoto, T. 1985. Toxicon 23, 271.
      Product Information
      CAS number4368-28-9
      ATP CompetitiveN
      DeclarationNot available for sale outside of the United States.
      FormWhite solid
      FormulationCrystalline solid. Contains sodium citrate.
      Hill FormulaC₁₁H₁₇N₃O₈
      Chemical formulaC₁₁H₁₇N₃O₈
      ReversibleY
      Quality LevelMQ100
      Applications
      ApplicationTetrodotoxin, Fugu sp., CAS 18660-81-6, is a reversible blocker of Na+ channels. Inhibits the release of glutamate via Na+-dependent glutamate transporter.
      Biological Information
      Primary TargetNa+ channels
      Primary Target IC<sub>50</sub>63 nM Iinhibiting the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca2+ accumulation
      Purity≥98%
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSIO1450000
      Safety Information
      R PhraseR: 28

      Very toxic if swallowed.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Activity is destroyed if exposed to alkaline or strongly acidic conditions.
      End use certificateY
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      554412-1MG 04055977193077

      Documentation

      Tetrodotoxin, Citrate, Fugu sp. - CAS 4368-28-9 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Tetrodotoxin, Citrate, Fugu sp. - CAS 4368-28-9 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      554412

      Referências

      Visão geral de referência
      Lysko, P.G., et al. 1994. Stroke 25, 2476.
      Hu, S.L. and Kao, C.Y. 1985. Toxicon 23, 723.
      Nakamura, M. and Yasumoto, T. 1985. Toxicon 23, 271.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-August-2008 JSW
      SynonymsTTx
      DescriptionReversibly blocks Na+ channels, which are essential for the propagation of impulses in excitable membranes. Useful as a marker of Na+ channels in excitable tissues. Inhibits the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca2+ accumulation (IC50 = 63 nM).
      FormWhite solid
      FormulationCrystalline solid. Contains sodium citrate.
      CAS number4368-28-9
      RTECSIO1450000
      Chemical formulaC₁₁H₁₇N₃O₈
      Purity≥98%
      SolubilityH₂O (1 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Activity is destroyed if exposed to alkaline or strongly acidic conditions.
      Toxicity Highly Toxic
      Merck USA index14, 9246
      ReferencesLysko, P.G., et al. 1994. Stroke 25, 2476.
      Hu, S.L. and Kao, C.Y. 1985. Toxicon 23, 723.
      Nakamura, M. and Yasumoto, T. 1985. Toxicon 23, 271.