Millipore Sigma Vibrant Logo

566405 Smad3 Inhibitor, SIS3 - CAS 1009104-85-1 - Calbiochem

Smad3 Inhibitor, SIS3, CAS 1009104-85-1, is a cell-permeable, selective inhibitor of TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated signaling. Does not affect Smad2, MAPK, ERK, or PI3-K.

Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: SIS3, 6,7-Dimethoxy-2-((2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-prop-2-enoyl))-1,2,3,4-tetrahydroisoquinoline, Specific Inhibitor of Smad3

Primary Target: TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling
View Products on Sigmaaldrich.com
566405
Ver preços e disponibilidade

Panorama geral

Replacement Information

Tabela com principais espec.

CAS #Empirical Formula
1009104-85-1C₂₈H₂₇N₃O₃

Preço e Disponibilidade

Número de catálogo DisponibilidadeEmbalagem Qtde/Emb. Preço Quantidade
566405-1MG
Verificando a disponibilidade...
—
Disponibilidade limitada Disponibilidade limitada
Insira quantidade 
Descontinuado
Quantidades limitadas disponíveis
Disponibilidade a ser confirmada
    Restante: será informado
      Restante: será informado
      Vai informar
      Contatar o serviço de atendimento ao cliente
      Contact Customer Service

      		 Ampola plástica 1 mg
      Recuperando preço...
      O preço não pôde ser recuperado
      Quantidade mínima necessária para ser múltipla de
      Maximum Quantity is
      Após finalização do pedido Mais informações
      Você salvou ()
       
      —
      Solicitar preço
      		 —
      Description
      OverviewA cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling with no effect on Smad2, p38 MAPK, ERK, or PI 3-K signaling.
      Catalogue Number566405
      Brand Family Calbiochem®
      SynonymsSIS3, 6,7-Dimethoxy-2-((2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-prop-2-enoyl))-1,2,3,4-tetrahydroisoquinoline, Specific Inhibitor of Smad3
      References
      ReferencesJinnin, M., et al. 2006. Mol. Pharmacol. 69, 597.
      Product Information
      CAS number1009104-85-1
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₈H₂₇N₃O₃
      Chemical formulaC₂₈H₂₇N₃O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      566405-1MG 04055977191516

      Documentation

      Smad3 Inhibitor, SIS3 - CAS 1009104-85-1 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Smad3 Inhibitor, SIS3 - CAS 1009104-85-1 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      566405

      Referências

      Visão geral de referência
      Jinnin, M., et al. 2006. Mol. Pharmacol. 69, 597.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      SynonymsSIS3, 6,7-Dimethoxy-2-((2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-prop-2-enoyl))-1,2,3,4-tetrahydroisoquinoline, Specific Inhibitor of Smad3
      DescriptionA cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling with no effect on Smad2, p38 MAPK, ERK, or PI 3-K signaling.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1009104-85-1
      Chemical formulaC₂₈H₂₇N₃O₃
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (15 mg/ml) or Ethanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesJinnin, M., et al. 2006. Mol. Pharmacol. 69, 597.