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03-0146-00 SMC™ Amyloid Beta 1-42 High Sensitivity Immunoassay Kit

The sensitivity of the Single Molecule Counting (SMC™) technology gives the SMC™ Amyloid Beta 1-42 (Aβ42) High Sensitivity Immunoassay Kit unparalleled performance in the quantification of Aβ42 in hum

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Key Applications: Single Molecule Counting (SMC®) Research Category: Neuroscience, Metabolism Research Sub-Category: Inflammation & Autoimmune Mechanisms, Metabolism, Obesity
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03-0146-00
96 well assay  
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      Key Applications
      Single Molecule Counting (SMC®)
      Description
      Catalogue Number03-0146-00
      Trade Name
      • SMC®
      DescriptionSMC™ Amyloid Beta 1-42 High Sensitivity Immunoassay Kit
      OverviewThe SMC™ Amyloid Beta 1-42 High Sensitivity Immunoassay Kit contains all reagents required to perform the assay. This assay takes advantage of a standard immunoassay workflow configured in a standard plate format. Assay protocols are similar to existing sandwich ELISA methods with two key differences: 1) Elution buffer disrupts the sandwich, separating the labeled detection antibody for quantification. 2) The Erenna® and SMCxPRO™ immunoassay systems detect analytes using Single Molecule Counting (SMC™) technology.
      Background InformationAmyloid Beta refers to the short peptides that are released into circulation following the proteolysis of the transmembrane protein amyloid precursor protein (APP), whose function is unclear but thought to be involved in neuronal development and function. The most common peptides generated from APP cleavage are Aβ1-40 and Aβ1-42, with the latter isoform implicated in the formation of toxic oligomers, fibrils, and plaques in the diseased brain. Reduced levels of soluble Aβ1-42 in the cerebrospinal fluid (CSF) are associated with Alzheimer’s disease (AD), leading to the adoption of this peptide as an AD biomarker.
      Product Information
      Components
      • SMC™ Amyloid Beta Assay Buffer
      • SMC™ Amyloid Beta 1-42 Coated Beads
      • SMC™ Amyloid Beta Standard Diluent
      • SMC™ Amyloid Beta Detection Antibody
      • SMC™ Amyloid Beta 1-42 Standard
      • 10X Wash Buffer
      • Buffer D
      • Elution Buffer B
      Precision, %
      • Intra-assay CV% average (n=20): <10%
      • Inter-assay CV% average (n=6): <10%
      Quality LevelMQ200
      Applications
      ApplicationThe sensitivity of the Single Molecule Counting (SMC™) technology gives the SMC™ Amyloid Beta 1-42 (Aβ42) High Sensitivity Immunoassay Kit unparalleled performance in the quantification of Aβ42 in human, mouse and rat cerebrospinal fluid (CSF) and plasma.
      Key Applications
      • Single Molecule Counting (SMC®)
      Biological Information
      Cross ReactivityNo significant cross-reactivity to Aβ38 and Aβ40 was observed.
      Accuracy
      • Minimum of 6 samples spiked with acceptable recovery between 80-120%.
      Physicochemical Information
      Sensitivity
      • Lower Limit of Quantification: 0.98 pg/mL
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Packaging Information
      Material Size96 well assay
      Global Trade Item Number
      Número de catálogo GTIN
      03-0146-00 04054839166433