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557508 Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem

A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC₅₀ = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC.

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Sinônimos: 2-[1-3(Aminopropyl)indol-3-yl]-3(1-methyl-1H-indol-3-yl)maleimide, Acetate, Bisindolylmaleimide VIII, Acetate

Primary Target: rat brain PKC
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Tabela com principais espec.

CAS #Empirical Formula
125313-65-7C₂₄H₂₂N₄O₂ · C₂H₄O₂ • H2O

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      Description
      OverviewA cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ1. Exhibits some degree of PKC isozyme specificity (IC50 = 53 nM for PKCα, 195 nM for PKCβI, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε). Inhibits carbachol-evoked noradrenaline release (IC50 = 600 nM).
      Catalogue Number557508
      Brand Family Calbiochem®
      Synonyms2-[1-3(Aminopropyl)indol-3-yl]-3(1-methyl-1H-indol-3-yl)maleimide, Acetate, Bisindolylmaleimide VIII, Acetate
      References
      ReferencesZhang, C., et al. 1997. J. Immunol. 158, 4968.
      Turner, N.A., et al. 1996. J. Neurochem. 66, 2381.
      Ozawa, K., et al. 1993. J. Biol. Chem. 268, 1749.
      Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
      Product Information
      CAS number125313-65-7
      ATP CompetitiveY
      FormRed to reddish-orange solid
      Hill FormulaC₂₄H₂₂N₄O₂ · C₂H₄O₂ • H2O
      Chemical formulaC₂₄H₂₂N₄O₂ · C₂H₄O₂ • H2O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetrat brain PKC
      Primary Target IC<sub>50</sub>158 nM against rat brain PKC; 53 nM for PKCα, 195 nM for PKCβ, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε
      Purity≥93% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      557508-1MG 04055977268126

      Documentation

      Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      557508

      Referências

      Visão geral de referência
      Zhang, C., et al. 1997. J. Immunol. 158, 4968.
      Turner, N.A., et al. 1996. J. Neurochem. 66, 2381.
      Ozawa, K., et al. 1993. J. Biol. Chem. 268, 1749.
      Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2010 RFH
      Synonyms2-[1-3(Aminopropyl)indol-3-yl]-3(1-methyl-1H-indol-3-yl)maleimide, Acetate, Bisindolylmaleimide VIII, Acetate
      DescriptionA cell-permeable, reversible, selective protein kinase C (PKC) inhibitor that acts at the ATP binding site of PKC (IC50 = 158 nM for rat brain PKC). Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ1 unlike staurosporine and other serine/threonine kinase inhibitors. IC50 values for individual PKC isozymes are as follows: 53 nM for PKCα, 195 nM for PKCβI, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε. Inhibits carbachol-evoked noradrenaline release (IC50 = 0.6 µM).
      FormRed to reddish-orange solid
      CAS number125313-65-7
      Chemical formulaC₂₄H₂₂N₄O₂ · C₂H₄O₂ • H2O
      Structure formulaStructure formula
      Purity≥93% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesZhang, C., et al. 1997. J. Immunol. 158, 4968.
      Turner, N.A., et al. 1996. J. Neurochem. 66, 2381.
      Ozawa, K., et al. 1993. J. Biol. Chem. 268, 1749.
      Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.