Millipore Sigma Vibrant Logo

553008 Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem

View Products on Sigmaaldrich.com
553008
Ver preços e disponibilidade

Panorama geral

Replacement Information

Tabela com principais espec.

CAS #Empirical Formula
220904-83-6C₁₅H₈Br₂INO₂

Preço e Disponibilidade

Número de catálogo DisponibilidadeEmbalagem Qtde/Emb. Preço Quantidade
553008-1MG
Verificando a disponibilidade...
Disponibilidade limitada
Disponibilidade limitada
Insira quantidade 
Descontinuado
Quantidades limitadas disponíveis
Disponibilidade a ser confirmada
    Restante: será informado
      Restante: será informado
      Vai informar
      Contatar o serviço de atendimento ao cliente
      Contact Customer Service

      Ampola plástica 1 mg
      Recuperando preço...
      O preço não pôde ser recuperado
      Quantidade mínima necessária para ser múltipla de
      Maximum Quantity is
      Após finalização do pedido Mais informações
      Você salvou ()
       
      Solicitar preço
      Description
      OverviewA potent, cell-permeable, reversible, and ATP-competitive cRAF1 kinase inhibitor (IC50 = 9 nM). Shows ≥100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-Src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms. Predicted broad spectrum antitumor agents. A 10 mM (500 µg/96 µl) solution of Raf1 Inhibitor I (Cat. No. 553003) in DMSO is also available.
      Catalogue Number553008
      Brand Family Calbiochem®
      Synonyms5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone, GW 5074
      References
      ReferencesLackey, K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 223.
      Product Information
      CAS number220904-83-6
      ATP CompetitiveY
      FormDark orange solid
      Hill FormulaC₁₅H₈Br₂INO₂
      Chemical formulaC₁₅H₈Br₂INO₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCRAFI kinase
      Primary Target IC<sub>50</sub>9 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.



      From Catalog:
      Desc. Field- added "Predicted broad spectrum antitumor agents.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      553008-1MG 04055977193404

      Documentation

      Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      553008

      Referências

      Visão geral de referência
      Lackey, K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 223.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-January-2010 RFH
      Synonyms5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone, GW 5074
      DescriptionA potent, cell-permeable, reversible, and ATP-competitive cRaf1 kinase inhibitor (IC50 = 9 nM). Shows ≥100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fms. cRaf1 inhibitors are predicted to be broad spectrum antitumor agents.
      FormDark orange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number220904-83-6
      Chemical formulaC₁₅H₈Br₂INO₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.



      From Catalog:
      Desc. Field- added "Predicted broad spectrum antitumor agents.
      Toxicity Standard Handling
      ReferencesLackey, K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 223.