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540220 Purmorphamine - CAS 483367-10-8 - Calbiochem

A cell-permeable activator of Hedgehog signaling that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC₅₀ = 1 µM).

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Sinônimos: 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist

Primary Target: Activation of the Hedgehog signaling pathway
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CAS #Empirical Formula
483367-10-8C₃₁H₃₂N₆O₂

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      Description
      OverviewA cell-permeable 2,6,9-trisubstituted purine compound that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC50 = 1 µM) and lineage-committed preosteoblasts MC3T3-E1. Its effect can be synergized with that of BMP-4 (bone morphogenetic protein-4) and has been shown to induce transdifferentiation even in preadipocytes and myoblasts. Reported to induce osteogenesis by activation of the Hedgehog signaling pathway. A 50 mM (5 mg/192 µl) solution of Purmorphamine (Cat. No. 540223) in DMSO is also available.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number540220
      Brand Family Calbiochem®
      Synonyms2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist
      References
      ReferencesWu, X., et al. 2004. Chem. Biol. 11, 1229.
      Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.
      Product Information
      CAS number483367-10-8
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₃₁H₃₂N₆O₂
      Chemical formulaC₃₁H₃₂N₆O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetActivation of the Hedgehog signaling pathway
      Primary Target IC<sub>50</sub>EC50 = 1 µM for inducing osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22-68

      Harmful if swallowed.
      Possible risks of irreversible effects.
      S PhraseS: 22-36/37

      Do not breathe dust.
      Wear suitable protective clothing and gloves.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      540220-5MG 07790788051389

      Documentation

      Purmorphamine - CAS 483367-10-8 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      540220

      Referências

      Visão geral de referência
      Wu, X., et al. 2004. Chem. Biol. 11, 1229.
      Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-November-2014 JSW
      Synonyms2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist
      DescriptionA cell-permeable purine compound that induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells (EC50 = 1 µM) and in MC3T3-E1 lineage-committed preosteoblasts. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Its effects are reported to be synergistic with bone morphogenetic protein-4 (BMP-4). Reported to induce osteogenesis by activation of the Hedgehog signaling pathway.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number483367-10-8
      Chemical formulaC₃₁H₃₂N₆O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesWu, X., et al. 2004. Chem. Biol. 11, 1229.
      Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.