Pellicon® 2 Microfiltration Cassettes
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| Antibody Purification |
| Dialysis and Filtration |
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| Pellicon® |
Categorias
| Biopharmaceutical Manufacturing > Downstream Processing > Ultrafiltration > Pellicon Cassettes > Pellicon 2 Cassettes |
The Pellicon® 2 product line was designed with process scale-up and applications development in mind. The series of devices includes the long established Durapore® hydrophilic PVDF microfiltration membrane, well known for its exceptional combination of high flux, low protein binding and high product recoveries.
Benefits
- Leading-edge void-free membranes to match virtually any separation challenge
- Short flow path for higher flux and higher resolution separation capability
- Choice of flow channel configuration providing process optimization capability
- Predictable, fast, scale-up
- True linear scalability from laboratory size modules to industrial assemblies for processing thousands of liters
Applications
- Clarification – of protein solutions, polysaccharide solutions, virus suspensions/cultures, cell lysates and pre-column streams
- Harvesting – of cell cultures and colloidal suspensions
- Harvesting and Washing – of colloidal suspensions, bacterial cells or viral cultures
| Normalized Recirculation Rates | ||
| Parameter | Unit | Typical ∆P |
| Screen Type | N/A | A C V |
| Recirculation Rate | L/min/m² | 4/6 5/35 |
| Differential Pressure | bar/psi | 1.4/20 0.4/6 |
| Screen Selection Guidelines | |
| Solution Type | Screen Type |
| Dilute protein solution or low viscosity solutions (mAbs, interferons) | A screen (tight screen) |
| Concentrated protein solutions or high viscosity solutions (IgG, biopolymers) | C screen (coarse screen) |
| High viscosity solutions (polysaccharides, certain microfiltration or clarification applications) | V screen (loose screen) |
| Specifications | |||
| Temperature Range | |||
| Mini, Cassette and Maxi: | 4 to 50 °C | ||
| Prefiltration Required | |||
| Mini, Cassette and Maxi: | 100 µm | ||
| Dimensions | |||
| Device | Width | Length | Thickness |
| Mini | 5.6 cm | 21 cm | 1.5 cm (V screen-2.16 cm) |
| Cassette | 17.8 cm | 21 cm | 1.5 cm (V screen-2.16 cm) |
| Maxi | 17.8 cm | 21 cm | 7.6 cm (V screen-9.0 cm) |
| Membrane Selection Chart | ||||
| Durapore Membranes | ||||
| Approximate Molecular Weight (range of solutes retained > 99%, kD) |
Membrane | NMWL (kD) or Microns | Membrane Material | pH Range |
| Clarify cell lysates and protein solutions, clarify viral cultures | VVPP | 0.1 µm | Hydrophilic PVDF | 2 – 11 |
| Harvest & wash colloidal suspensions, bacterial cells; clarify protein solutions and viral cultures | GVPP | 0.22 µm | Hydrophilic PVDF | 2 – 11 |
| Harvest & wash colloidal suspensions, cell & viral cultures; clarify protein solutions & viral cultures | HVMP | 0.45 µm | Hydrophilic PVDF | 2 – 11 |
| Harvest cell cultures or colloidal suspensions | DVPP | 0.65 µm | Hydrophilic PVDF | 2 – 11 |