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580555 Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem

Antitumor and antileukemic agent isolated from the bark of the yew tree.

Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: Baccatin III N-benzyl-β-phenylisoserine Ester, TAXOL®

Primary Target: Promotes assembly of microtubules and inhibits tubulins disassembly
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CAS #Empirical Formula
33069-62-4C₄₇H₅₁NO₁₄

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      Description
      OverviewAntitumor and antileukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
      Catalogue Number580555
      Brand Family Calbiochem®
      SynonymsBaccatin III N-benzyl-β-phenylisoserine Ester, TAXOL®
      References
      ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
      Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
      Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
      Hornback, N.B., et al. 1994. In Vivo 8, 819.
      Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
      Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
      Ding, A.H., et al. 1990. Science 248, 370.
      Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
      Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
      Product Information
      CAS number33069-62-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₄₇H₅₁NO₁₄
      Chemical formulaC₄₇H₅₁NO₁₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPromotes assembly of microtubules and inhibits tubulins disassembly
      Purity≥95% by NMR
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDA8340700
      Safety Information
      R PhraseR: 37/38-41-46-60

      Irritating to respiratory system and skin.
      Risk of serious damage to eyes.
      May cause heritable genetic damage.
      May impair fertility.
      S PhraseS: 22-26-36/37/39-45

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      580555-25MG 04055977265514

      Documentation

      Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      580555

      Referências

      Visão geral de referência
      Derry, W.B., et al. 1995. Biochemistry 34, 2203.
      Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
      Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
      Hornback, N.B., et al. 1994. In Vivo 8, 819.
      Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
      Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
      Ding, A.H., et al. 1990. Science 248, 370.
      Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
      Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.

      Brochura

      Título
      Caspases and other Apoptosis Related Tools Brochure
      Tools and Tips for Analyzing Apoptosis
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-December-2024 JSW
      SynonymsBaccatin III N-benzyl-β-phenylisoserine Ester, TAXOL®
      DescriptionAntitumor and anti-leukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
      FormWhite solid
      CAS number33069-62-4
      RTECSDA8340700
      Chemical formulaC₄₇H₅₁NO₁₄
      Structure formulaStructure formula
      Purity≥95% by NMR
      SolubilityDMSO (10 mg/ml) or Methanol (1 mg/ml)
      Storage Protect from moisture
      Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 6982
      ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
      Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
      Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
      Hornback, N.B., et al. 1994. In Vivo 8, 819.
      Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
      Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
      Ding, A.H., et al. 1990. Science 248, 370.
      Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
      Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.