529573 Sigma-AldrichPP2 - CAS 172889-27-9 - Calbiochem
PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC₅₀ = 4, 5, 5, &100 nM for p56lck, p59fynT, Hck, & Src, respectively).
More>> PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC₅₀ = 4, 5, 5, &100 nM for p56lck, p59fynT, Hck, & Src, respectively). Less<<PP2 - CAS 172889-27-9 - Calbiochem: Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.
Sinônimos: AG 1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
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Panorama geral
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Tabela com principais espec.
| CAS # | Empirical Formula |
|---|---|
| 172889-27-9 | C₁₅H₁₆ClN₅ |
Preço e Disponibilidade
| Número de catálogo | Disponibilidade | Embalagem | Qtde/Emb. | Preço | Quantidade | |
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| 529573-1MG |
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Ampola plástica | 1 mg |
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| 529573-5MG |
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Frasco de vidro | 5 mg |
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| Description | |
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| Overview | A potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. Inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM). Does not significantly affect the activity of EGFR kinase (IC50 = 480 nM), JAK2 (IC50 > 50 µM), or ZAP-70 (IC50 >100 µM). Inhibits the activation of focal adhesion kinase and its phosphorylation at Tyr577. Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC50 = 600 nM). A 10 mM (1 mg/331 µl) solution of PP2 (Cat. No. 529576) in DMSO also available. |
| Catalogue Number | 529573 |
| Brand Family | Calbiochem® |
| Synonyms | AG 1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine |
| References | |
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| References | Karni, R., et al. 2003. FEBS Lett. 537, 47. Salazar, E.P., and Rozengurt, E. 1999. J. Biol. Chem. 274, 28371. Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76. |
| Product Information | |
|---|---|
| CAS number | 172889-27-9 |
| ATP Competitive | Y |
| Form | Off-white solid |
| Hill Formula | C₁₅H₁₆ClN₅ |
| Chemical formula | C₁₅H₁₆ClN₅ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Physicochemical Information | |
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| Cell permeable | N |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Número de catálogo | GTIN |
| 529573-1MG | 07790788051198 |
| 529573-5MG | 04055977269802 |
Documentation
PP2 - CAS 172889-27-9 - Calbiochem MSDS
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PP2 - CAS 172889-27-9 - Calbiochem Certificados de análise
| Título | Número do lote |
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| 529573 |
Referências
| Visão geral de referência |
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| Karni, R., et al. 2003. FEBS Lett. 537, 47. Salazar, E.P., and Rozengurt, E. 1999. J. Biol. Chem. 274, 28371. Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76. |
Brochura
| Título |
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| An Introduction to Inhibitors and Their Biological Applications - 1st Edition |
| Bulk Product Guide |
Informações técnicas
| Título |
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| Fluorescent Gelatin Degradation Assays for Investigating Invadopodia Formation |
Ficha de dados
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| Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation |
Pôster
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| Human Kinome & InhibitorSelect™ Libraries |
Citações
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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