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527455 PKR Inhibitor, Negative Control - CAS 852547-30-9 - Calbiochem

The PKR Inhibitor, Negative Control, also referenced under CAS 852547-30-9, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: RNA-Dependent Protein Kinase Inhibitor, Negative Control, 5-Chloro-3-(3,5-dichloro-4-hydroxybenzylidene)-1,3-dihydro-indol-2-one

Primary Target: A negative control for PKR Inhibitor
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527455
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CAS #Empirical Formula
852547-30-9C₁₅H₈Cl₃NO₂

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      Description
      OverviewAn oxindole compound that serves as a negative control for PKR Inhibitor (Cat. No. 527450). Shown to be inactive in inhibiting RNA-induced PKR autophosphorylation (IC50 > 100 µM) or in rescuing PKR-dependent translation block.
      Catalogue Number527455
      Brand Family Calbiochem®
      SynonymsRNA-Dependent Protein Kinase Inhibitor, Negative Control, 5-Chloro-3-(3,5-dichloro-4-hydroxybenzylidene)-1,3-dihydro-indol-2-one
      References
      ReferencesJammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
      Product Information
      CAS number852547-30-9
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₅H₈Cl₃NO₂
      Chemical formulaC₁₅H₈Cl₃NO₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetA negative control for PKR Inhibitor
      Purity≥95% by HPLC (sum of two isomers)
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      527455-10MG 04055977270389

      Documentation

      PKR Inhibitor, Negative Control - CAS 852547-30-9 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      PKR Inhibitor, Negative Control - CAS 852547-30-9 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      527455

      Referências

      Visão geral de referência
      Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-September-2007 JSW
      SynonymsRNA-Dependent Protein Kinase Inhibitor, Negative Control, 5-Chloro-3-(3,5-dichloro-4-hydroxybenzylidene)-1,3-dihydro-indol-2-one
      DescriptionAn oxindole compound that serves as a negative control for PKR Inhibitor (Cat. No. 527450). Shown to be inactive in the inhibition of RNA-induced PKR autophosphorylation (IC50 > 100 µM). Exhibits no ability to rescue the translational block imposed by human PKR.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number852547-30-9
      Chemical formulaC₁₅H₈Cl₃NO₂
      Structure formulaStructure formula
      Purity≥95% by HPLC (sum of two isomers)
      SolubilityDMSO (10 mg/ml) or Ethanol (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.