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495620 Olomoucine - CAS 101622-51-9 - Calbiochem

A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B and related kinases.

Olomoucine - CAS 101622-51-9 - Calbiochem: Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: Olomoucine

Primary Target: p34cdk1/cyclin B
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495620
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CAS #Empirical Formula
101622-51-9C₁₅H₁₈N₆O

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      Description
      OverviewA purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B (IC50 = 7 µM) and related kinases including p33cdk2/cyclin A (IC50 = 7 µM), p33cdk2/cyclin E (IC50 = 7 µM), p33cdk5/p35 (IC50 = 3 µM), and p44 MAP kinase (IC50 = 25 µM). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D (IC50 > 1 mM), and p40cdk6/cyclin D3 (IC50 > 250 µM). Does not significantly affect the activity of other protein kinases at 1 mM. Known to inhibit DNA synthesis in interleukin-2-stimulated T lymphocytes and trigger G1 arrest similar to that observed in interleukin-2-deprived cells. Also used to synchronize cells in G1. A 50 mM (5 mg/336 µl) solution of Olomoucine (Cat. No. 495624) in DMSOis also available.
      Catalogue Number495620
      Brand Family Calbiochem®
      SynonymsOlomoucine
      References
      ReferencesAbraham, R.T., et al. 1995. Biol. Cell 83, 105.
      Mistelli, T., and Warren, G. 1995. J. Cell Sci. 108, 2715.
      Glab, N., et al. 1994. FEBS Lett. 353, 207.
      Veselý, J., et al. 1994. Eur. J. Biochem. 224, 771.
      Product Information
      CAS number101622-51-9
      ATP CompetitiveY
      FormCrystalline solid
      Hill FormulaC₁₅H₁₈N₆O
      Chemical formulaC₁₅H₁₈N₆O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetp34cdk1/cyclin B
      Primary Target IC<sub>50</sub>7 µM, 7 µM, 7 µM, 3 µM, 25 µM against p34cdk1/cyclin B, p33cdk2/cyclin A, p33cdk2/cyclin E, p33cdk5/p35, and p44 MAP kinase, respectively
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      495620-1MG 04055977199789

      Documentation

      Olomoucine - CAS 101622-51-9 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Olomoucine - CAS 101622-51-9 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      495620

      Referências

      Visão geral de referência
      Abraham, R.T., et al. 1995. Biol. Cell 83, 105.
      Mistelli, T., and Warren, G. 1995. J. Cell Sci. 108, 2715.
      Glab, N., et al. 1994. FEBS Lett. 353, 207.
      Veselý, J., et al. 1994. Eur. J. Biochem. 224, 771.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-April-2018 JSW
      SynonymsOlomoucine
      DescriptionA purine derivative that acts as a potent, reversible, and selective inhibitor of p34cdc2/cyclin B (IC50 = 7 µM) and related kinases, including p33cdk2/cyclin A (IC50 = 7 µM), p33cdk2/cyclin E (IC50 = 7 µM), p33cdk5/p35 (IC50 = 3 µM), and p44MAPK (IC50 = 25 µM). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D1 (IC50 > 1000 µM) and p40cdk6/cyclin D3 (IC50 > 250 µM). Does not significantly affect the activity of other protein kinases even at 1 mM concentrations. Known to inhibit DNA synthesis in interleukin-2 stimulated T lymphocytes and triggers G1 arrest similar to that observed in interleukin-2 deprived cells. Also used to synchronize cells in G1.
      FormCrystalline solid
      CAS number101622-51-9
      Chemical formulaC₁₅H₁₈N₆O
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesAbraham, R.T., et al. 1995. Biol. Cell 83, 105.
      Mistelli, T., and Warren, G. 1995. J. Cell Sci. 108, 2715.
      Glab, N., et al. 1994. FEBS Lett. 353, 207.
      Veselý, J., et al. 1994. Eur. J. Biochem. 224, 771.