480401 Sigma-AldrichNFAT Inhibitor, Cell-Permeable - Calbiochem
The NFAT Inhibitor, Cell-Permeable controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
More>> The NFAT Inhibitor, Cell-Permeable controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. Less<<NFAT Inhibitor, Cell-Permeable - Calbiochem: Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.
Sinônimos: 11R-VIVIT, Nuclear Factor of Activated T cells Inhibitor, RRRRRRRRRRR-GGG-MAGPHPVIVITGPHEE
Produtos recomendados
Panorama geral
| Replacement Information |
|---|
Tabela com principais espec.
| Empirical Formula |
|---|
| C₁₄₇H₂₅₉N₆₇O₃₆S |
Preço e Disponibilidade
| Número de catálogo | Disponibilidade | Embalagem | Qtde/Emb. | Preço | Quantidade | |
|---|---|---|---|---|---|---|
| 480401-1MG |
|
Ampola plástica | 1 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable version of NFAT Inhibitor (Cat. No. 480402) that is modified at the N-terminal with an eleven arginine transduction domain and a three glycine linker sequence. Prevents the activation and proliferation of T cells both in vitro ( ~ 43% at 1 µM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice). Shown to be effective in providing immunosuppression in a murine islet xenograft model. Unlike Cyclosporin A (Cat. No. 239835) and FK506, 11R-VIVIT does not cause side effects outside the immune system as a result of calcineurin (Cat. No. 539568) inhibition and therefore serves as a less toxic alternative for in vivo applications. The functional half-life of 11R-VIVIT has been estimated to be ~30 h in Jurkat cells. |
| Catalogue Number | 480401 |
| Brand Family | Calbiochem® |
| Synonyms | 11R-VIVIT, Nuclear Factor of Activated T cells Inhibitor, RRRRRRRRRRR-GGG-MAGPHPVIVITGPHEE |
| References | |
|---|---|
| References | Noguchi, H., et al. 2004. Nat. Med. 10, 305. |
| Product Information | |
|---|---|
| ATP Competitive | N |
| Form | Lyophilized white solid |
| Formulation | Supplied as a trifluoroacetate salt. |
| Hill Formula | C₁₄₇H₂₅₉N₆₇O₃₆S |
| Chemical formula | C₁₄₇H₂₅₉N₆₇O₃₆S |
| Hygroscopic | Hygroscopic |
| Reversible | N |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Primary Target | NFAT |
| Primary Target IC<sub>50</sub> | Use at 1 µM for preventing the activation and proliferation of T cells |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Peptide Sequence | H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Número de catálogo | GTIN |
| 480401-1MG | 07790788050641 |
Documentation
NFAT Inhibitor, Cell-Permeable - Calbiochem MSDS
| Título |
|---|
NFAT Inhibitor, Cell-Permeable - Calbiochem Certificados de análise
| Título | Número do lote |
|---|---|
| 480401 |
Referências
| Visão geral de referência |
|---|
| Noguchi, H., et al. 2004. Nat. Med. 10, 305. |