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616382 Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem

Inhibits trypsin-like serine proteinases.

Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: TLCK

Primary Target: trypsin like proteases
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616382
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Tabela com principais espec.

CAS #Empirical Formula
4238-41-9C₁₄H₂₁ClN₂O₃S . HCl

Preço e Disponibilidade

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616382-250MG
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      Description
      OverviewInhibits trypsin-like serine proteinases. Irreversibly inactivates trypsin without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to the target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC50 = 80 µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemia cells and normal thymocytes.
      Catalogue Number616382
      Brand Family Calbiochem®
      SynonymsTLCK
      References
      ReferencesGriscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Kim, H., et al. 1995. J. Immunol. 154, 4741.
      Bourinbaiar, A.S. and Nagorny, R. 1994. Cell Immunol. 155, 230.
      Biro, A., et al. 1992. Eur. J. Immunol. 22, 2547.
      Bruno, S., et al. 1992. Leukemia 6, 1113.
      Lee, S.F. 1992. Infect. Immun. 60, 4032.
      Schmidt, H.H., et al. 1992. Mol. Pharmacol. 41, 615.
      Product Information
      CAS number4238-41-9
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₄H₂₁ClN₂O₃S . HCl
      Chemical formulaC₁₄H₂₁ClN₂O₃S . HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targettrypsin like proteases
      Primary Target IC<sub>50</sub>EC50 = 80 µM blocking nitric oxide synthase induced by interferon-γ and lipopolysaccharides in macrophages
      Purity≥95% by elemental analysis
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSXT5160000
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      616382-250MG 04055977186284

      Documentation

      Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      616382

      Referências

      Visão geral de referência
      Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Kim, H., et al. 1995. J. Immunol. 154, 4741.
      Bourinbaiar, A.S. and Nagorny, R. 1994. Cell Immunol. 155, 230.
      Biro, A., et al. 1992. Eur. J. Immunol. 22, 2547.
      Bruno, S., et al. 1992. Leukemia 6, 1113.
      Lee, S.F. 1992. Infect. Immun. 60, 4032.
      Schmidt, H.H., et al. 1992. Mol. Pharmacol. 41, 615.

      Brochura

      Título
      Caspases and other Apoptosis Related Tools Brochure

      Citações

      Título
    • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
      		•
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-September-2008 JSW
      SynonymsTLCK
      DescriptionInhibits trypsin-like serine proteases. Inactivates trypsin irreversibly without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC50 = 80 µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes. Suggesting working concentration is 10-100 µM.
      FormOff-white solid
      CAS number4238-41-9
      RTECSXT5160000
      Chemical formulaC₁₄H₂₁ClN₂O₃S . HCl
      Structure formulaStructure formula
      Purity≥95% by elemental analysis
      SolubilityAqueous solutions pH <6.0 (1 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Irritant
      ReferencesGriscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Kim, H., et al. 1995. J. Immunol. 154, 4741.
      Bourinbaiar, A.S. and Nagorny, R. 1994. Cell Immunol. 155, 230.
      Biro, A., et al. 1992. Eur. J. Immunol. 22, 2547.
      Bruno, S., et al. 1992. Leukemia 6, 1113.
      Lee, S.F. 1992. Infect. Immun. 60, 4032.
      Schmidt, H.H., et al. 1992. Mol. Pharmacol. 41, 615.
      Citation
    • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
      		•