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475872 MnTMPyP - Calbiochem

Cell-permeable superoxide dismutase (SOD) mimetic.

MnTMPyP - Calbiochem: Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin, Tetratosylate, Hydroxide

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Replacement Information

Tabela com principais espec.

Empirical Formula
C₇₂H₆₅MnN₈O₁₃S₄

Preço e Disponibilidade

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475872-25MG
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      Description
      OverviewCell-permeable superoxide dismutase (SOD) mimetic. Catalyzes the dismutation of O2– • (rate constant ~4 x 107 M-1 s-1) even in the presence of excess EDTA. Can substitute for SOD in mutants of E. coli lacking this enzyme. MnTMPyP acts in vivo as an NADPH/GSH:O2• oxidoreductase rather than as an SOD mimetic. Also an efficient peroxynitrite reductase when redox-coupled with biological antioxidants.
      Catalogue Number475872
      Brand Family Calbiochem®
      SynonymsMn(III)tetrakis(1-methyl-4-pyridyl)porphyrin, Tetratosylate, Hydroxide
      References
      ReferencesIzbicka, E., et al. 1999. Cancer Res. 59, 639.
      Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 6053.
      Gardner, P.R., et al. 1996. Arch. Biochem. Biophys. 325, 20.
      Liochev, S.I., and Fridovich, I. 1995. Arch. Biochem. Biophys. 321, 271.
      Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.
      Product Information
      ATP CompetitiveN
      FormBlack solid
      Hill FormulaC₇₂H₆₅MnN₈O₁₃S₄
      Chemical formulaC₇₂H₆₅MnN₈O₁₃S₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSuperoxide dismutase (SOD) mimetic
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      475872-25MG 04055977203431

      Documentation

      MnTMPyP - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      MnTMPyP - Calbiochem Certificados de análise

      TítuloNúmero do lote
      475872

      Referências

      Visão geral de referência
      Izbicka, E., et al. 1999. Cancer Res. 59, 639.
      Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 6053.
      Gardner, P.R., et al. 1996. Arch. Biochem. Biophys. 325, 20.
      Liochev, S.I., and Fridovich, I. 1995. Arch. Biochem. Biophys. 321, 271.
      Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

      Brochura

      Título
      Pathways and Biomarkers of Oxidative Stress

      Citações

      Título
    • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
      		•
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-August-2008 JSW
      SynonymsMn(III)tetrakis(1-methyl-4-pyridyl)porphyrin, Tetratosylate, Hydroxide
      DescriptionCell-permeable superoxide dismutase (SOD) mimetic. Catalyzes the dismutation of O2– • (rate constant ~4 x 107 M-1 s-1) even in the presence of excess EDTA. Can substitute for SOD in mutants of E. coli lacking this enzyme. MnTMPyP acts in vivo as an NADPH/GSH:O2• oxidoreductase rather than as an SOD mimetic. Also an efficient peroxynitrite reductase when redox-coupled with biological antioxidants.
      FormBlack solid
      Chemical formulaC₇₂H₆₅MnN₈O₁₃S₄
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityH₂O (1 mg/ml)
      Storage Protect from moisture
      Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesIzbicka, E., et al. 1999. Cancer Res. 59, 639.
      Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 6053.
      Gardner, P.R., et al. 1996. Arch. Biochem. Biophys. 325, 20.
      Liochev, S.I., and Fridovich, I. 1995. Arch. Biochem. Biophys. 321, 271.
      Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.
      Citation
    • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
      		•