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509663 MCT1 Inhibitor, SR13800 - CAS 227321-12-2 - Calbiochem

A cell-permeable inhibitor of monocarboxylate transporter 1 (MCT1). Blocks the proliferation of Raji Burkitt lymphoma cells expressing MCT1 (EC₅₀ = 5 nM).

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Sinônimos: Monocarboxylate Transport I Inhibitor, SLC16A1 Inhibitor

Primary Target: MCT1
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CAS #Empirical Formula
227321-12-2C₂₅H₂₉N₃O₂S

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      Description
      OverviewA cell-permeable pyrole pyrimidine-based compound that acts as an inhibitor of monocarboxylate transporter 1 (MCT1, SLC16A1) and blocks the proliferation of Raji Burkitt lymphoma (Raji BL) cells expressing MCT1 (EC50 = 5 nM). Also shown to inhibit the growth of MCF-7 breast cancer cells. Effectively increases intracellular lactate levels while reducing lactate export and intracellular ATP levels in Raji cells. However, it does not affect basal oxygen consumption or the mitochondrial mass in these cells. Delays or even eliminates tumor growth in NOD/SCID mice injected with Raji lymphoma cells. Acts synergistically with metformin (Cat. No. 317240) to block monocarboxylate transport and tumor growth in humans and in murine models. Their combined effect also reduces cellular levels of glutathione with concomitant increase in hydrogen peroxide levels, which increases the death of Raji BL cells.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number509663
      Brand Family Calbiochem®
      SynonymsMonocarboxylate Transport I Inhibitor, SLC16A1 Inhibitor
      References
      ReferencesDoherty, J., et al. 2014. Cancer Res. 73,908.
      Murray, C., et al. 2013. Nature. Chem. Biol. 1, 371.
      Product Information
      CAS number227321-12-2
      FormWhite powder
      Hill FormulaC₂₅H₂₉N₃O₂S
      Chemical formulaC₂₅H₂₉N₃O₂S
      Quality LevelMQ200
      Applications
      Biological Information
      Primary TargetMCT1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      5096630001 04055977240993

      Documentation

      MCT1 Inhibitor, SR13800 - CAS 227321-12-2 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Referências

      Visão geral de referência
      Doherty, J., et al. 2014. Cancer Res. 73,908.
      Murray, C., et al. 2013. Nature. Chem. Biol. 1, 371.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2014 JSW
      SynonymsMonocarboxylate Transport I Inhibitor, SLC16A1 Inhibitor
      DescriptionA cell-permeable pyrole pyrimidine-based compound that acts as an inhibitor of monocarboxylate transporter 1 (MCT1, SLC16A1) and blocks the proliferation of Raji Burkitt lymphoma (Raji BL) cells expressing MCT1 (EC50 = 5 nM). Also shown to inhibit the growth of MCF-7 breast cancer cells. Effectively increases intracellular lactate levels while reducing lactate export and intracellular ATP levels in Raji cells. However, it does not affect basal oxygen consumption or the mitochondrial mass in these cells. Delays or even eliminates tumor growth in NOD/SCID mice injected with Raji lymphoma cells. Acts synergistically with metformin (Cat. No. 317240) to block monocarboxylate transport and tumor growth in humans and in murine models. Their combined effect also reduces cellular levels of glutathione with concomitant increase in hydrogen peroxide levels, which increases the death of Raji BL cells.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number227321-12-2
      Chemical formulaC₂₅H₂₉N₃O₂S
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDoherty, J., et al. 2014. Cancer Res. 73,908.
      Murray, C., et al. 2013. Nature. Chem. Biol. 1, 371.