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437725 Lipoxin A₄, 15-epi - CAS 171030-11-8 - Calbiochem

Lipoxin A₄, 15-epi, CAS 171030-11-8, is an epimeric lipoxin A4 (Cat. No. 437720) analog that is more potent and metabolically stable than LXA4.

Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: LXA₄-15-epi, 15(R)-LXA₄, Aspirin-triggered LXA₄, (5S,6R,15R)-5,6,15-Trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid

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437725
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CAS #Empirical Formula
171030-11-8C₂₀H₃₂O₅

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      Description
      OverviewA epimeric lipoxin A4 (Cat. No. 437720) analog that is more potent and metabolically stable than LXA4. Exhibits anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte trafficking/infiltration. Blocks TNF-α-induced IL-8 release in human enterocyte. It is also an important modulator of the many pharmacological actions caused by aspirin.
      Caution! Product contains volatile liquid. Keep product cold at all times.
      Catalogue Number437725
      Brand Family Calbiochem®
      SynonymsLXA₄-15-epi, 15(R)-LXA₄, Aspirin-triggered LXA₄, (5S,6R,15R)-5,6,15-Trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid
      References
      ReferencesWallace, J.L., and Fiorucci, S. 2003. Trends Pharmacol. Sci. 24, 323.
      Filep, J.G., et al. 2002. Adv. Exp. Med. Biol. 507, 223.
      Titos, E., et al. 1999. Am. J. Physiol. 277, C870.
      Gronert, K., et al. 1998. J. Exp. Med. 187, 1285.
      Maddox, J.F., et al. 1997. J. Biol. Chem. 272, 6972.
      Claria, J., et al. 1996. Mol. Med. 2, 583.
      Claria, J., and Serhan, C.N. 1995. Proc. Natl. Acad. Sci. USA 92, 9475.
      Serhan, C.N., et al. 1995. Biochemistry 34, 14609.
      Product Information
      CAS number171030-11-8
      ATP CompetitiveN
      FormLiquid
      FormulationIn Ethanol.
      Hill FormulaC₂₀H₃₂O₅
      Chemical formulaC₂₀H₃₂O₅
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetExhibits anti-inflammatory properties
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Flammable
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw aliquot and freeze (-70°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      437725-25UG 04055977186895

      Documentation

      Lipoxin A₄, 15-epi - CAS 171030-11-8 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Lipoxin A₄, 15-epi - CAS 171030-11-8 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      437725

      Referências

      Visão geral de referência
      Wallace, J.L., and Fiorucci, S. 2003. Trends Pharmacol. Sci. 24, 323.
      Filep, J.G., et al. 2002. Adv. Exp. Med. Biol. 507, 223.
      Titos, E., et al. 1999. Am. J. Physiol. 277, C870.
      Gronert, K., et al. 1998. J. Exp. Med. 187, 1285.
      Maddox, J.F., et al. 1997. J. Biol. Chem. 272, 6972.
      Claria, J., et al. 1996. Mol. Med. 2, 583.
      Claria, J., and Serhan, C.N. 1995. Proc. Natl. Acad. Sci. USA 92, 9475.
      Serhan, C.N., et al. 1995. Biochemistry 34, 14609.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-August-2008 RFH
      SynonymsLXA₄-15-epi, 15(R)-LXA₄, Aspirin-triggered LXA₄, (5S,6R,15R)-5,6,15-Trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid
      DescriptionAn epimeric lipoxin A4 (Cat. No. 437720) analog that is more potent and metabolically stable than LXA4. Exhibits anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte trafficking/infiltration. Reported to block TNF-α-induced IL-8 release in human enterocytes. Also reported to be an important modulator of the pharmacological actions of aspirin.

      Caution! Product contains volatile liquid; keep cold at all times.
      FormLiquid
      FormulationIn Ethanol.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number171030-11-8
      Chemical formulaC₂₀H₃₂O₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage Protect from light
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw aliquot and freeze (-70°C).
      Toxicity Flammable
      ReferencesWallace, J.L., and Fiorucci, S. 2003. Trends Pharmacol. Sci. 24, 323.
      Filep, J.G., et al. 2002. Adv. Exp. Med. Biol. 507, 223.
      Titos, E., et al. 1999. Am. J. Physiol. 277, C870.
      Gronert, K., et al. 1998. J. Exp. Med. 187, 1285.
      Maddox, J.F., et al. 1997. J. Biol. Chem. 272, 6972.
      Claria, J., et al. 1996. Mol. Med. 2, 583.
      Claria, J., and Serhan, C.N. 1995. Proc. Natl. Acad. Sci. USA 92, 9475.
      Serhan, C.N., et al. 1995. Biochemistry 34, 14609.