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361552 InSolution™ GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem

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361552
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CAS #Empirical Formula
667463-62-9C₁₆H₁₀BrN₃O₂

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      Description
      Catalogue Number361552
      Brand Family Calbiochem®
      References
      ReferencesPolychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Sato, N., et al. 2004. Nat. Med. 10, 55.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
      Product Information
      CAS number667463-62-9
      ATP CompetitiveY
      FormLiquid
      FormulationA 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.
      Hill FormulaC₁₆H₁₀BrN₃O₂
      Chemical formulaC₁₆H₁₀BrN₃O₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGSK-3α/β
      Primary Target IC<sub>50</sub>5 nM against GSK-3α/β
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      361552-500UG 04055977214109

      Documentation

      InSolution™ GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      InSolution™ GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      361552

      Referências

      Visão geral de referência
      Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Sato, N., et al. 2004. Nat. Med. 10, 55.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-March-2008 JSW
      DescriptionA cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Specificity was confirmed using various Cdk's (IC50 = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC50 ≥ 10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs).
      FormLiquid
      FormulationA 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number667463-62-9
      Chemical formulaC₁₆H₁₀BrN₃O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Toxicity Carcinogenic / Teratogenic
      ReferencesPolychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Sato, N., et al. 2004. Nat. Med. 10, 55.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.

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      Categorias

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Glycogen Synthase Kinase (GSK) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Cyclin-Dependent Kinase (Cdk) Inhibitors