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538256 IDO Inhibitor - CAS 914471-09-3 - Calbiochem

A cell-potent, bioavailable, non-toxic hydroxyamidine that acts as a selective and D-trp competitive IDO inhibitor. Rapidly decreases cellular kynurenine levels & inhibits B16-GM-CSF melanoma tumor growth.

IDO Inhibitor - CAS 914471-09-3 - Calbiochem: Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: 4-Amino-N-(3-chloro-4-fluorophenyl)-Nʹ-hydroxy-1,2,5-oxadiazole-3-carboximidamide, IDOi, Indoleamine 2,3-Dioxygenase Inhibitor

Primary Target: IDO
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Tabela com principais espec.

CAS #Empirical Formula
914471-09-3C₉H₇ClFN₅O₂

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      Description
      OverviewA cell-permeable, bioactive, non-toxic oxadiazolohydroxyamidine based compound that acts as a potent, selective and competitive inhibitor of indoleamine 2,3-dioxygenase (IDO; IC50 = 67 nM for hIDO). Reversibly binds to the catalytically active heme iron (Fe2+) and is inactive towards closely related tryptophan 2,3-dioxygenase (TDO; IC50 > 10 µM). Shown to dose-dependently decrease kynurenine levels (IC50 = 19 & 46 nM in HeLa treated with IFN-γ & B16-GM-CSF melanoma cells, respectively) and suppress B16-GM-CSF xenograft tumor growth in C57BL/6 mice (75 mg/kg, s.c., b.i.d.). Though orally bioavailable, but undergoes a rapid clearance (t1/2 < 0.5 h).

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number538256
      Brand Family Calbiochem®
      Synonyms4-Amino-N-(3-chloro-4-fluorophenyl)-Nʹ-hydroxy-1,2,5-oxadiazole-3-carboximidamide, IDOi, Indoleamine 2,3-Dioxygenase Inhibitor
      DescriptionIDO Inhibitor
      References
      ReferencesYue, E.W., et al. 2009. J. Med. Chem. 52, 7364.
      Product Information
      CAS number914471-09-3
      FormOff-white powder
      Hill FormulaC₉H₇ClFN₅O₂
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetIDO
      Primary Target IC<sub>50</sub>67 nM for hIDO
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      5382560001 04054839059513

      Documentation

      IDO Inhibitor - CAS 914471-09-3 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      IDO Inhibitor - CAS 914471-09-3 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      538256

      Referências

      Visão geral de referência
      Yue, E.W., et al. 2009. J. Med. Chem. 52, 7364.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-June-2016 JSW
      Synonyms4-Amino-N-(3-chloro-4-fluorophenyl)-Nʹ-hydroxy-1,2,5-oxadiazole-3-carboximidamide, IDOi, Indoleamine 2,3-Dioxygenase Inhibitor
      DescriptionA cell-permeable, bioactive, non-toxic oxadiazolohydroxyamidine based compound that acts as a potent, selective and competitive inhibitor of indoleamine 2,3-dioxygenase (IDO; IC50 = 67 nM for hIDO). Reversibly binds to the catalytically active heme iron (Fe2+) and is inactive towards closely related tryptophan 2,3-dioxygenase (TDO; IC50 > 10 µM). Shown to dose-dependently decrease kynurenine levels (IC50 = 19 & 46 nM in HeLa treated with IFN-γ & B16-GM-CSF melanoma cells, respectively) and suppress B16-GM-CSF xenograft tumor growth in C57BL/6 mice (75 mg/kg, s.c., b.i.d.). Though orally bioavailable, but undergoes a rapid clearance (t1/2 < 0.5 h).
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number914471-09-3
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesYue, E.W., et al. 2009. J. Med. Chem. 52, 7364.