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3779 Histamine, Free Base - CAS 51-45-6 - Calbiochem

A potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase.

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Sinônimos: 2-(4-Imidazolyl)ethylamine

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3779
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CAS #Empirical Formula
51-45-6C₅H₉N₃

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      Description
      OverviewA potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase. Formed by the decarboxylation of L-histidine. Activation of histamine H1 receptors leads to Ca2+ mobilization, whereas histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Stimulated time- and concentration-dependent increase in p38 and p42/p44 MAP kinases in DDT(1) MF2 cells.
      Catalogue Number3779
      Brand Family Calbiochem®
      Synonyms2-(4-Imidazolyl)ethylamine
      References
      ReferencesRobinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178.
      Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477.
      Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952.
      Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
      Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
      Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.
      Product Information
      CAS number51-45-6
      FormWhite solid
      Hill FormulaC₅H₉N₃
      Chemical formulaC₅H₉N₃
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSMS1050000
      Safety Information
      R PhraseR: 22-36/37/38-42/43

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause sensitization by inhalation and skin contact.
      S PhraseS: 26-36/37-22

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing and gloves.
      Do not breathe dust.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      3779-1GM 07790788049744

      Documentation

      Histamine, Free Base - CAS 51-45-6 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Histamine, Free Base - CAS 51-45-6 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      3779

      Referências

      Visão geral de referência
      Robinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178.
      Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477.
      Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952.
      Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
      Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
      Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-June-2011 JSW
      Synonyms2-(4-Imidazolyl)ethylamine
      DescriptionA potent vasodilator found in normal tissues and blood. Formed by the decarboxylation of L-histidine. Activates nitric oxide synthase (NOS), resulting in the release of nitric oxide. Activation of histamine H1 receptors leads to Ca2+ mobilization; whereas, histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number51-45-6
      RTECSMS1050000
      Chemical formulaC₅H₉N₃
      Structure formulaStructure formula
      Purity≥97% by TLC
      SolubilityH₂O (1 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 4719
      ReferencesRobinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178.
      Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477.
      Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952.
      Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
      Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
      Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.