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345887 Ginkgolic Acid (15:1) - CAS 22910-60-7 - Calbiochem

Ginkgolic Acid (15:1), CAS 22910-60-7, is a cell-permeable analog of anacardic acid that inhibits protein SUMOylation (IC50 = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner.

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Sinônimos: Histone Acetyltransferase Inhibitor VI, PCAF Inhibitor II, SUMOylation Inhibitor, (Z)-6-(Pentadec-8-enyl)-2-hydroxybenzoic acid, HAT Inhibitor VI

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345887
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CAS #Empirical Formula
22910-60-7C₂₂H₃₄O₃

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      Description
      OverviewA cell-permeable anacardic acid (Cat. No. 172050) analog that inhibits protein SUMO (Cat. Nos. 662037, 662039, and 662042) modification (IC50 = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. Nos. 662073 and 662074) and interfering with E1-SUMO intermediate formation independent of E1 active site cysteine. Both ginkgolic acid and anacardic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins, including p53, in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although both compounds are shown to inhibit histone lysine acetylation by PCAF (Cat. No. 124026) in cell-free acetylase assays. Also available as a 25 mM solution in DMSO (Cat. No. 508197).
      Catalogue Number345887
      Brand Family Calbiochem®
      SynonymsHistone Acetyltransferase Inhibitor VI, PCAF Inhibitor II, SUMOylation Inhibitor, (Z)-6-(Pentadec-8-enyl)-2-hydroxybenzoic acid, HAT Inhibitor VI
      References
      ReferencesFukuda, I., et al. 2009. Chem. Biol. 16, 133.
      Product Information
      CAS number22910-60-7
      FormWhite solid
      Hill FormulaC₂₂H₃₄O₃
      Chemical formulaC₂₂H₃₄O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationGinkgolic Acid (15:1), CAS 22910-60-7, is a cell-permeable analog of anacardic acid that inhibits protein SUMOylation (IC50 = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner.
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing intitial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      345887-5MG 04055977214543

      Documentation

      Ginkgolic Acid (15:1) - CAS 22910-60-7 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Ginkgolic Acid (15:1) - CAS 22910-60-7 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      345887

      Referências

      Visão geral de referência
      Fukuda, I., et al. 2009. Chem. Biol. 16, 133.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-April-2010 RFH
      SynonymsHistone Acetyltransferase Inhibitor VI, PCAF Inhibitor II, SUMOylation Inhibitor, (Z)-6-(Pentadec-8-enyl)-2-hydroxybenzoic acid, HAT Inhibitor VI
      DescriptionA cell-permeable anacardic acid (Cat. No. 172050) analog that inhibits protein SUMO (Cat. No. 662037, 662039, and 662042) modification (IC50 = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. No. 662073 and 662074) and interfering with E1-SUMO intermediate formation independent of E1 active site cysteine. Both ginkgolic acid and anacardic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins, including p53, in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although both compounds are shown to inhibit histone lysine acetylation by PCAF (Cat. No. 124026) in cell-free acetylase assays.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number22910-60-7
      Chemical formulaC₂₂H₃₄O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing intitial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesFukuda, I., et al. 2009. Chem. Biol. 16, 133.