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361559 GSK-3 Inhibitor XVI - CAS 252917-06-9 - Calbiochem

GSK-3 Inhibitor XVI - CAS 252917-06-9, is a cell-permeable, potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC₅₀ = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively).

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Sinônimos: 6-(2-(4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino)ethyl-amino)-nicotinonitrile, CHIR99021

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361559
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CAS #Empirical Formula
252917-06-9C₂₂H₁₈Cl₂N₈

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      Description
      OverviewA cell-permeable aminopyrimidine compound that acts as potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC50 = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively). Exhibits little or no activity toward 46 other enzymes (IC50 >8.8 µM against 20 kinases and Ki ≥5 µM against 23 non-kinase enzymes) and shows only weak binding to 22 pharmacologically relevant receptors (Kd ~4 µM). This compound is orally available and is shown to effectively improve glucose metabolism in both murine and rat type 2 diabetes models in vivo. Also available as a 25 mM solution in DMSO (Cat. No. 361571).
      Catalogue Number361559
      Brand Family Calbiochem®
      Synonyms6-(2-(4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino)ethyl-amino)-nicotinonitrile, CHIR99021
      References
      ReferencesMussmann, R., et al. 2007. J. Biol. Chem. 282, 12030.
      Ring, D.B., et al. 2003. Diabetes 52, 588.
      Bennett, C.N., et al. 2002. J. Biol. Chem. 277, 30998.
      Cline, G.W., et al. 2002. Diabetes 51, 2903.
      Product Information
      CAS number252917-06-9
      FormWhite to beige solid
      Hill FormulaC₂₂H₁₈Cl₂N₈
      Chemical formulaC₂₂H₁₈Cl₂N₈
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Biological Information
      Purity≥95% by HPLC
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 22-24/25-36-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de catálogo GTIN
      361559-5MG 04055977214208