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344827 Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose - Calbiochem

2F-Peracetyl-Fucose is a cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic.

Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: (3S,4R,5R,6S)-3-fluoro-6-methyltetrahydro-2H-pyran-2,4,5-triyl triacetate

Primary Target: Fucosyltransferase
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Tabela com principais espec.

Empirical Formula
C₁₂H₁₇FO₇

Preço e Disponibilidade

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344827-10MG
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      Description
      OverviewA cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic. Treatment of HL-60 cells with this inhibitor shows complete abolition of Lewis-X and SLex within 3 days. Also abolishes P-selectin binding and exhibits faster rolling cells on E-selectin and P-selectin coated surfaces. Does not affect cell viability or their doubling time even at 200 µM levels.
      Catalogue Number344827
      Brand Family Calbiochem®
      Synonyms(3S,4R,5R,6S)-3-fluoro-6-methyltetrahydro-2H-pyran-2,4,5-triyl triacetate
      References
      ReferencesRillahan, C., et al. 2012.. Nat. Chem. Bio. 8, 661.
      Product Information
      FormWhite solid
      Hill FormulaC₁₂H₁₇FO₇
      Chemical formulaC₁₂H₁₇FO₇
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ300
      Applications
      Biological Information
      Primary TargetFucosyltransferase
      Purity≥98% by NMR
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      344827-10MG 04055977214833

      Documentation

      Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose - Calbiochem Certificados de análise

      TítuloNúmero do lote
      344827

      Referências

      Visão geral de referência
      Rillahan, C., et al. 2012.. Nat. Chem. Bio. 8, 661.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-October-2012 JSW
      Synonyms(3S,4R,5R,6S)-3-fluoro-6-methyltetrahydro-2H-pyran-2,4,5-triyl triacetate
      DescriptionA cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic. Treatment of HL-60 cells with this inhibitor shows complete abolition of Lewis-X and SLex within 3 days. Also abolishes P-selectin binding and exhibits faster rolling cells on E-selectin and P-selectin coated surfaces. Does not affect cell viability or their doubling time even at 200 µM levels.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₂H₁₇FO₇
      Structure formulaStructure formula
      Purity≥98% by NMR
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesRillahan, C., et al. 2012.. Nat. Chem. Bio. 8, 661.