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324693 Emetine, Dihydrochloride - CAS 316-42-7 - Calbiochem

Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha.

Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: 6ʹ,7ʹ,10,11-Tetramethoxyemetan, 2HCl

Primary Target: Movement of ribosomes along the mRNA
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CAS #Empirical Formula
316-42-7C₂₉H₄₀N₂O₄ · 2HCl

Preço e Disponibilidade

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324693-250MG
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      Description
      OverviewPrincipal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Interferes with cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC50 ≤1 µM.
      Catalogue Number324693
      Brand Family Calbiochem®
      Synonyms6ʹ,7ʹ,10,11-Tetramethoxyemetan, 2HCl
      References
      ReferencesKong, H.S., et al. 2010. Mol. Pharmacol. in press.
      Khan, M.A. 1995. Prog. Neurobiol. 46, 541.
      Kokuho, T., et al. 1995. Immunobiology 193, 42.
      Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett. 93, 157.
      Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
      Filley, E.A., and Rook, G.A. 1991. Infect. Immun. 59, 2567.
      Landis, R.C., et al. 1991. J. Immunol. 146, 128.
      Schweighoffer, T., et al. 1991. Histochemistry 96, 93.
      Product Information
      CAS number316-42-7
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₂₉H₄₀N₂O₄ · 2HCl
      Chemical formulaC₂₉H₄₀N₂O₄ · 2HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMovement of ribosomes along the mRNA
      Primary Target IC<sub>50</sub>≤1 µM as a specific inhibitor of HIF-2α protein stability and transcriptional activity
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSJY5250000
      Safety Information
      R PhraseR: 28-36/38

      Very toxic if swallowed.
      Irritating to eyes and skin.
      S PhraseS: 28-36/37-45


      Wear suitable protective clothing and gloves.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      324693-250MG 04055977215885

      Documentation

      Emetine, Dihydrochloride - CAS 316-42-7 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Emetine, Dihydrochloride - CAS 316-42-7 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      324693

      Referências

      Visão geral de referência
      Kong, H.S., et al. 2010. Mol. Pharmacol. in press.
      Khan, M.A. 1995. Prog. Neurobiol. 46, 541.
      Kokuho, T., et al. 1995. Immunobiology 193, 42.
      Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett. 93, 157.
      Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
      Filley, E.A., and Rook, G.A. 1991. Infect. Immun. 59, 2567.
      Landis, R.C., et al. 1991. J. Immunol. 146, 128.
      Schweighoffer, T., et al. 1991. Histochemistry 96, 93.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-April-2019 JSW
      Synonyms6ʹ,7ʹ,10,11-Tetramethoxyemetan, 2HCl
      DescriptionPrinciple alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC50 ≤1 µM.
      FormWhite to off-white solid
      CAS number316-42-7
      RTECSJY5250000
      Chemical formulaC₂₉H₄₀N₂O₄ · 2HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityEthanol or H₂O (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Highly Toxic
      Merck USA index14, 3559
      ReferencesKong, H.S., et al. 2010. Mol. Pharmacol. in press.
      Khan, M.A. 1995. Prog. Neurobiol. 46, 541.
      Kokuho, T., et al. 1995. Immunobiology 193, 42.
      Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett. 93, 157.
      Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
      Filley, E.A., and Rook, G.A. 1991. Infect. Immun. 59, 2567.
      Landis, R.C., et al. 1991. J. Immunol. 146, 128.
      Schweighoffer, T., et al. 1991. Histochemistry 96, 93.