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324461 E2F Inhibitor, HLM006474 - CAS 353519-63-8 - Calbiochem

The E2F Inhibitor, HLM006474, also referenced under CAS 353519-63-8, controls the biological activity of E2F. This small molecule/inhibitor is primarily used for Cancer applications.

Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: 7-((4-Ethoxy-3-methylphenyl)(2-pyridylamino)methyl)-2-methyl-quinolinol

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      Description
      OverviewA cell-permeable 8-hydroxyquinoline compound that is reported to inhibit nuclear E2F complexes DNA binding activity (IC50 = 30 µM) and downregulate E2F expression in the melanoma cell line A375, resulting in eventual apoptosis induction without upregulating p53 expression as commonly seen with traditional chemotherapeutic agents, such as Cisplatin (Cat. No. 232120), doxorubicin (Cat. No. 324380), and VP-16 (Cat. No. 341205).
      Catalogue Number324461
      Brand Family Calbiochem®
      Synonyms7-((4-Ethoxy-3-methylphenyl)(2-pyridylamino)methyl)-2-methyl-quinolinol
      References
      ReferencesMa, Y., et al. 2008. Cancer Res. 68, 6292.
      Product Information
      CAS number353519-63-8
      FormOff-white solid
      Hill FormulaC₂₅H₂₅N₃O₂
      Chemical formulaC₂₅H₂₅N₃O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      324461-10MG 04055977197211

      Documentation

      E2F Inhibitor, HLM006474 - CAS 353519-63-8 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      E2F Inhibitor, HLM006474 - CAS 353519-63-8 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      324461

      Referências

      Visão geral de referência
      Ma, Y., et al. 2008. Cancer Res. 68, 6292.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2011 RFH
      Synonyms7-((4-Ethoxy-3-methylphenyl)(2-pyridylamino)methyl)-2-methyl-quinolinol
      DescriptionA cell-permeable 8-hydroxyquinoline compound that is reported to inhibit nuclear E2F complexes DNA binding activity (IC50 = 30 µM) and downregulate E2F expression in the melanoma cell line A375, resulting in eventual apoptosis induction without upregulating p53 expression as commonly seen with traditional chemotherapeutic agents, such as Cisplatin (Cat. No. 232120), doxorubicin (Cat. No. 324380), and VP-16 (Cat. No. 341205).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number353519-63-8
      Chemical formulaC₂₅H₂₅N₃O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMa, Y., et al. 2008. Cancer Res. 68, 6292.