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324410 Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem

Dynamin Inhibitor I, Dynasore, CAS 304448-55-3, is a cell-permeable inhibitor of the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1. Has no significant effect on MxA and Cdc42.

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Sinônimos: 3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin

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CAS #Empirical Formula
304448-55-3C₁₈H₁₄N₂O₄

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      Description
      OverviewA cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane.
      Catalogue Number324410
      Brand Family Calbiochem®
      Synonyms3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin
      References
      ReferencesYoung, A., et al. 2009. Biochem. J. , In press.
      Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol. 16, 607.
      Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 17955.
      Macia. E., et al. 2006. Dev. Cell 10, 839.
      Product Information
      CAS number304448-55-3
      FormPale yellow solid
      Hill FormulaC₁₈H₁₄N₂O₄
      Chemical formulaC₁₈H₁₄N₂O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationDynamin Inhibitor I, Dynasore, CAS 304448-55-3, is a cell-permeable inhibitor of the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1. Has no significant effect on MxA and Cdc42.
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 50

      Very toxic to aquatic organisms.
      S PhraseS: 22-24/25

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Environmental Hazard
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      324410-10MG 04055977197167

      Documentation

      Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      324410

      Referências

      Visão geral de referência
      Young, A., et al. 2009. Biochem. J. , In press.
      Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol. 16, 607.
      Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 17955.
      Macia. E., et al. 2006. Dev. Cell 10, 839.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-May-2009 RFH
      Synonyms3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin
      DescriptionA cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number304448-55-3
      Chemical formulaC₁₈H₁₄N₂O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (16 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Environmental Hazard
      ReferencesYoung, A., et al. 2009. Biochem. J. , In press.
      Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol. 16, 607.
      Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 17955.
      Macia. E., et al. 2006. Dev. Cell 10, 839.