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232120 Cisplatin - CAS 15663-27-1 - Calbiochem

Cisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation.

Cisplatin - CAS 15663-27-1 - Calbiochem: Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: CPDC, DDP, cis-Diaminedichloroplatinum

Primary Target: Induces apoptosis in cancer cells
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232120
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CAS #Empirical Formula
15663-27-1Pt(NH₃)₂Cl₂

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      Description
      OverviewA platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Reported to sensitize glioma cells to TNF-α-induced apoptosis.

      Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.
      Catalogue Number232120
      Brand Family Calbiochem®
      SynonymsCPDC, DDP, cis-Diaminedichloroplatinum
      References
      ReferencesHall, M.D., et al. 2014. Cancer Res. In press.
      Duan, L., et al. 2001. J. Neurooncol. 52, 23.
      Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
      Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother. 16, 279.
      Product Information
      CAS number15663-27-1
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaPt(NH₃)₂Cl₂
      Chemical formulaPt(NH₃)₂Cl₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetInduces apoptosis in cancer cells
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSTP2450000
      Safety Information
      R PhraseR: 25-36/37/38-45-42/43

      Toxic if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause cancer.
      May cause sensitization by inhalation and skin contact.
      S PhraseS: 22-24-37-45-53

      Do not breathe dust.
      Avoid contact with skin.
      Wear suitable gloves.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid exposure - obtain special instructions before use.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      232120-50MG 04055977217605

      Documentation

      Cisplatin - CAS 15663-27-1 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Cisplatin - CAS 15663-27-1 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      232120

      Referências

      Visão geral de referência
      Hall, M.D., et al. 2014. Cancer Res. In press.
      Duan, L., et al. 2001. J. Neurooncol. 52, 23.
      Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
      Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother. 16, 279.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-July-2014 JSW
      SynonymsCPDC, DDP, cis-Diaminedichloroplatinum
      DescriptionA platinum coordination complex with potent antineoplastic activity.

      Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.
      FormYellow solid
      CAS number15663-27-1
      RTECSTP2450000
      Chemical formulaPt(NH₃)₂Cl₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml), H₂O with 154 mM NaCl (1 mg/ml), or PBS with 140 mM NaCl (1 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 2317
      ReferencesHall, M.D., et al. 2014. Cancer Res. In press.
      Duan, L., et al. 2001. J. Neurooncol. 52, 23.
      Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
      Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother. 16, 279.