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227036 Cholera Toxin, Vibrio cholerae, Type Inaba 569B, Azide Free - CAS 9012-63-9 - Calbiochem

Cholera toxin Inaba 569B, CAS 9012-63-9, has a single A subunit surrounded by five polypeptides chains of the B subunits. The A subunit catalyzes the ADP-ribosylation of the α-subunit of G-proteins.

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227036
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CAS #
9012-63-9

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227036-1MG
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      Description
      OverviewUseful for studies involving adenylate cyclase, AMP, and related membrane-transport phenomena. Consists of a single A subunit surrounded by five polypeptide chains of the B subunits. The A subunit catalyzes the ADP-ribosylation of the α-subunit of G-proteins, reducing intrinsic GTPase activity and activating the α-subunit. The B subunits are responsible for the attachment of the native toxin on the cell surface.
      Useful for tissue culture applications.
      Catalogue Number227036
      Brand Family Calbiochem®
      References
      ReferencesGilman, A.G. 1987. Annu. Rev. Biochem. 56, 615.
      Product Information
      CAS number9012-63-9
      ActivityBinding activity is assessed by hemagglutination assay using trisialoganglioside fixed sheep red blood cells.
      ATP CompetitiveN
      DeclarationNot available for sale outside of the United States.
      FormSolid
      FormulationLyophilized from 200 mM NaCl, 50 mM Tris, 1 mM EDTA, pH 7.5.
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetα-subunit of G-proteins
      Purity≥95% by SDS-PAGE
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSLF3100000
      Safety Information
      R PhraseR: 21/22-36/37/38

      Harmful in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 7-36/37

      Keep container tightly closed.
      Wear suitable protective clothing and gloves.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Yes
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C under sterile conditions.
      End use certificateY
      Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      227036-1MG 04055977200560

      Documentation

      Cholera Toxin, Vibrio cholerae, Type Inaba 569B, Azide Free - CAS 9012-63-9 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Cholera Toxin, Vibrio cholerae, Type Inaba 569B, Azide Free - CAS 9012-63-9 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      227036

      Referências

      Visão geral de referência
      Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615.

      Brochura

      Título
      Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-March-2024 JSW
      DescriptionUseful for studies involving adenylate cyclase, AMP, and related membrane-transport phenomena. Consists of a single A subunit surrounded by five polypeptide chains of the B subunits. The A subunit catalyzes the ADP-ribosylation of the α-subunit of G-proteins, reducing intrinsic GTPase activity and activating the α-subunit. The B subunits are responsible for the attachment of the native toxin on the cell surface..
      FormSolid
      FormulationLyophilized from 200 mM NaCl, 50 mM Tris, 1 mM EDTA, pH 7.5.
      Concentration Label Please refer to vial label for lot-specific concentration
      CAS number9012-63-9
      RTECSLF3100000
      Purity≥95% by SDS-PAGE
      ActivityBinding activity is assessed by hemagglutination assay using trisialoganglioside fixed sheep red blood cells.
      SolubilityPlease refer to the vial label for lot-specific reconstitution. Note: cholera toxin tends to breakdown into its A and B subunits when the solution is frozen or with vigorous shaking during reconstitution, resulting in damage to the toxin protein and concomitant loss of biological activity. Swirl bottles gently during reconstitution. Avoid vigorous pipetting of solutions that would lead to foaming. Heating of cholera toxin in excess of 40-50°C results in aggregation and subsequent breakdown into its A and B subunits.
      Storage +2°C to +8°C
      Do Not Freeze Yes
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C under sterile conditions.
      Toxicity Highly Toxic
      ReferencesGilman, A.G. 1987. Annu. Rev. Biochem. 56, 615.