220285 Sigma-AldrichChelerythrine Chloride - CAS 3895-92-9 - Calbiochem
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Panorama geral
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Tabela com principais espec.
CAS # | Empirical Formula |
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3895-92-9 | C₂₁H₁₈NO₄Cl |
Preço e Disponibilidade
Número de catálogo | Disponibilidade | Embalagem | Qtde/Emb. | Preço | Quantidade | |
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220285-5MG |
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Ampola plástica | 5 mg |
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Description | |
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Overview | Naturally-occurring alkaloid. Potent, selective, and cell-permeable inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain of PKC. A competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. |
Catalogue Number | 220285 |
Brand Family | Calbiochem® |
Product Information | |
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CAS number | 3895-92-9 |
ATP Competitive | N |
Form | Light yellow to yellow solid |
Hill Formula | C₂₁H₁₈NO₄Cl |
Chemical formula | C₂₁H₁₈NO₄Cl |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
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Biological Information | |
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Primary Target | PKC |
Primary Target IC<sub>50</sub> | 660 nM |
Purity | ≥97% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
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Toxicological Information |
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Safety Information according to GHS | |
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RTECS | FL9200000 |
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Specifications |
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Global Trade Item Number | |
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Número de catálogo | GTIN |
220285-5MG | 07790788048761 |
Documentation
Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem MSDS
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Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem Certificados de análise
Título | Número do lote |
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220285 |
Referências
Visão geral de referência |
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Kandasamy, R.A., et al. 1995. J. Biol. Chem. 270 29209. Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707. Barg, J., et al. 1992. J. Neurochem. 59, 1145. Herbert, J.M., et al. 1990. Biochem. Biophys. Res. Commun. 172, 993. Ko, F., et al. 1990. Biochim. Biophys. Acta 1052, 360. Walterova, D., et al. J. Med. Chem. 24, 1100. |