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208925 Camptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem

A cell-permeable DNA topoisomerase I inhibitor.

Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: 4-Ethyl-4-hydroxy-1H-pyrano[3ʹ,4ʹ:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione

Primary Target: DNA topoisomerase 1
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CAS #Empirical Formula
7689-03-4C₂₀H₁₆N₂O₄

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      Description
      OverviewA cell-permeable DNA topoisomerase I inhibitor. Exhibits anti-leukemic and antitumor properties. Induces apoptosis in HL-60 cells and mouse thymocytes. Arrests cells at the G2/M phase.
      Catalogue Number208925
      Brand Family Calbiochem®
      Synonyms4-Ethyl-4-hydroxy-1H-pyrano[3ʹ,4ʹ:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
      References
      ReferencesJones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475.
      Staron, K., et al. 1994. Carcinogenesis 15, 2953.
      Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836.
      Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249.
      Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
      Pantazis, P., et al. 1993. Int. J. Cancer 53, 863.
      Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984.
      Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629.
      Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287.
      Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.
      Product Information
      CAS number7689-03-4
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₂₀H₁₆N₂O₄
      Chemical formulaC₂₀H₁₆N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDNA topoisomerase 1
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUQ0492000
      Safety Information
      R PhraseR: 25-36/37/38-46

      Toxic if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause heritable genetic damage.
      S PhraseS: 22-26-36/37/39-45

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      208925-50MG 04055977219128

      Documentation

      Camptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Camptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      208925

      Referências

      Visão geral de referência
      Jones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475.
      Staron, K., et al. 1994. Carcinogenesis 15, 2953.
      Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836.
      Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249.
      Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
      Pantazis, P., et al. 1993. Int. J. Cancer 53, 863.
      Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984.
      Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629.
      Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287.
      Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.

      Brochura

      Título
      Caspases and other Apoptosis Related Tools Brochure
      Tools and Tips for Analyzing Apoptosis
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-July-2009 RFH
      Synonyms4-Ethyl-4-hydroxy-1H-pyrano[3ʹ,4ʹ:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
      DescriptionA cell-permeable, reversible DNA topoisomerase I inhibitor that binds to and stabilizes the topoisomerase-DNA covalent complex. Possesses antileukemic and antitumor properties. Inhibits Tat-mediated transactivation of HIV-1. Cytostatic for non-tumorigenic cells but cytotoxic for tumorigenic cells. Induces apoptosis of HL-60 cells and mouse thymocytes.
      FormPale yellow solid
      CAS number7689-03-4
      RTECSUQ0492000
      Chemical formulaC₂₀H₁₆N₂O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) and MeOH (40 mg/ml). Stock solutions made with methanol will remain cloudy.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 1735
      ReferencesJones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475.
      Staron, K., et al. 1994. Carcinogenesis 15, 2953.
      Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836.
      Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249.
      Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
      Pantazis, P., et al. 1993. Int. J. Cancer 53, 863.
      Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984.
      Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629.
      Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287.
      Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.