Millipore Sigma Vibrant Logo

208902 Calpastatin Peptide - Calbiochem

A 27-amino acid, cell-permeable peptide encoded by exon 1B of human calpastatin that acts as a potent inhibitor of calpain I and calpain II (IC₅₀ = 20 nM for purified rabbit calpain II).

Calpastatin Peptide - Calbiochem: Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: CS Peptide

Primary Target: calpain 2
View Products on Sigmaaldrich.com
208902
Ver preços e disponibilidade

Panorama geral

Replacement Information

Tabela com principais espec.

Empirical Formula
C₁₄₂H₂₃₀N₃₆O₄₄S

Preço e Disponibilidade

Número de catálogo DisponibilidadeEmbalagem Qtde/Emb. Preço Quantidade
208902-500UG
Verificando a disponibilidade...
—
Disponibilidade limitada Disponibilidade limitada
Insira quantidade 
Descontinuado
Quantidades limitadas disponíveis
Disponibilidade a ser confirmada
    Restante: será informado
      Restante: será informado
      Vai informar
      Contatar o serviço de atendimento ao cliente
      Contact Customer Service

      		 Frasco de vidro 500 μg
      Recuperando preço...
      O preço não pôde ser recuperado
      Quantidade mínima necessária para ser múltipla de
      Maximum Quantity is
      Após finalização do pedido Mais informações
      Você salvou ()
       
      —
      Solicitar preço
      		 —
      Description
      OverviewA 27-amino acid, cell-permeable peptide encoded by exon 1B of human calpastatin that acts as a potent inhibitor of calpain I and calpain II (IC50 = 20 nM for purified rabbit calpain II). Does not inhibit either papain or trypsin. Blocks the down-regulation of protein kinase Cε (PKCε) in rat pituitary GH4C1 cells stimulated by thyrotropin-releasing hormone (TRH).
      Catalogue Number208902
      Brand Family Calbiochem®
      SynonymsCS Peptide
      References
      ReferencesEto, A., et al. 1995. J. Biol. Chem. 270, 25115.
      Kawasaki, J., et al. 1989. J. Biochem. 106, 274.
      Maki, M., et al. 1989. J. Biol. Chem. 264, 18866.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₄₂H₂₃₀N₃₆O₄₄S
      Chemical formulaC₁₄₂H₂₃₀N₃₆O₄₄S
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcalpain 2
      Primary Target IC<sub>50</sub>20 nM against calpain II
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceAc-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      208902-500UG 04055977219500

      Documentation

      Calpastatin Peptide - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Calpastatin Peptide - Calbiochem Certificados de análise

      TítuloNúmero do lote
      208902

      Referências

      Visão geral de referência
      Eto, A., et al. 1995. J. Biol. Chem. 270, 25115.
      Kawasaki, J., et al. 1989. J. Biochem. 106, 274.
      Maki, M., et al. 1989. J. Biol. Chem. 264, 18866.

      Citações

      Título
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
      		•
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-May-2008 RFH
      SynonymsCS Peptide
      DescriptionA 27-amino acid, peptide encoded by exon 1B of human calpastatin that acts as a cell-permeable and potent inhibitor of calpain I and calpain II (IC50 = 20 nM for purified rabbit calpain II). Does not inhibit either papain or trypsin. Blocks the down-regulation of protein kinase Cε (PKCε) in rat pituitary GH4C1 cells stimulated by thyrotropin-releasing hormone (TRH).
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Chemical formulaC₁₄₂H₂₃₀N₃₆O₄₄S
      Peptide SequenceAc-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH₂
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml) or 1% Acetic Acid (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesEto, A., et al. 1995. J. Biol. Chem. 270, 25115.
      Kawasaki, J., et al. 1989. J. Biochem. 106, 274.
      Maki, M., et al. 1989. J. Biol. Chem. 264, 18866.
      Citation
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
      		•