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208713 Calpain-1, Human Erythrocytes

Calpain-1, Human Erythrocytes, is a native calpain-1. A heterodimeric cysteine proteinase with low Ca2+ requirement (EC₅₀ = 2 µM).

Calpain-1, Human Erythrocytes: Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: μ-Calpain

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208713
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Preço e Disponibilidade

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208713-500UG
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      Description
      OverviewNative calpain-1 from human erythrocytes. Ca2+-dependent heterodimeric cysteine proteinase with low Ca2+ requirement (EC50= 2 µM).
      Catalogue Number208713
      Brand Family Calbiochem®
      Synonymsμ-Calpain
      References
      ReferencesVanderklish, P.W., and Bahr, B.A. 2000. Int. J. Exp. Pathol. 81, 323.
      Sorimachi, H., et al. 1997. Biochem. J. 328, 721.
      Croall, D.E., and McGrody, K.S. 1994. Biochemistry 33, 13223.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1 pmol Suc-LLVY-AMC in 1 min, 25°C using the Calpain Activity Assay Kit, Fluorogenic (Cat. No. QIA120). Note: 1 caseinolytic unit = 1 fluorogenic unit.
      EC number3.4.22.17
      FormLiquid
      FormulationIn 20 mM imidazole, 5 mM β-mercaptoethanol, 1 mM EDTA, 1 mM EGTA, 30% glycerol, pH 6.8.
      Quality LevelMQ100
      Applications
      Biological Information
      PurityComparable to reference lot by SDS-PAGE
      SourcePrepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Specific Activity≥1000 units/mg protein
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38-42/43

      Irritating to eyes, respiratory system and skin.
      May cause sensitization by inhalation and skin contact.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Harmful
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      208713-500UG 07790788048501

      Documentation

      Calpain-1, Human Erythrocytes MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Calpain-1, Human Erythrocytes Certificados de análise

      TítuloNúmero do lote
      208713

      Referências

      Visão geral de referência
      Vanderklish, P.W., and Bahr, B.A. 2000. Int. J. Exp. Pathol. 81, 323.
      Sorimachi, H., et al. 1997. Biochem. J. 328, 721.
      Croall, D.E., and McGrody, K.S. 1994. Biochemistry 33, 13223.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-January-2009 JSW
      Synonymsμ-Calpain
      DescriptionNative calpain-1 from human erythrocytes. Ca2+-dependent cysteine proteinase with low Ca2+ requirement (half-maximal activation = 2 µM). Participates in the ATP release reaction of platelets stimulated with thrombin.
      FormLiquid
      FormulationIn 20 mM imidazole, 5 mM β-mercaptoethanol, 1 mM EDTA, 1 mM EGTA, 30% glycerol, pH 6.8.
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      EC number3.4.22.17
      PurityComparable to reference lot by SDS-PAGE
      Specific activity≥1000 units/mg protein
      Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1 pmol Suc-LLVY-AMC in 1 min, 25°C using the Calpain Activity Assay Kit, Fluorogenic (Cat. No. QIA120). Note: 1 caseinolytic unit = 1 fluorogenic unit.
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Harmful
      ReferencesVanderklish, P.W., and Bahr, B.A. 2000. Int. J. Exp. Pathol. 81, 323.
      Sorimachi, H., et al. 1997. Biochem. J. 328, 721.
      Croall, D.E., and McGrody, K.S. 1994. Biochemistry 33, 13223.

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