203290 Sigma-AldrichBisindolylmaleimide I - CAS 133052-90-1 - Calbiochem
Bisindolylmaleimide I, CAS 133052-90-1, is a cell-permeable, highly selective, reversible inhibitor of protein kinase C (IC50 = 10 nM). Acts on the ATP-binding site of PKC.
More>> Bisindolylmaleimide I, CAS 133052-90-1, is a cell-permeable, highly selective, reversible inhibitor of protein kinase C (IC50 = 10 nM). Acts on the ATP-binding site of PKC. Less<<Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.
Sinônimos: 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide, Gö 6850, GF 109203X
Produtos recomendados
Panorama geral
| Replacement Information |
|---|
Tabela com principais espec.
| CAS # | Empirical Formula |
|---|---|
| 133052-90-1 | C₂₅H₂₄N₄O₂ |
Preço e Disponibilidade
| Número de catálogo | Disponibilidade | Embalagem | Qtde/Emb. | Preço | Quantidade | |
|---|---|---|---|---|---|---|
| 203290-1MG |
|
Ampola plástica | 1 mg |
|
— | |
| 203290-250UG |
|
Ampola plástica | 250 μg |
|
— |
| Description | |
|---|---|
| Overview | A highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (IC50 = 10 nM) that is structurally similar to staurosporine. Acts as a competitive inhibitor for the ATP-binding site of PKC. Shows high selectivity for PKCα-, βI-, βII-, γ-, δ-, and ε- isozymes. Potently inhibits GSK-3 in primary adipocyte lysates (IC50 = 360 nM) and in GSK-3β immunoprecipitates (IC50 = 170 nM). May inhibit protein kinase A at a much higher concentration (IC50 = 2 µM). A 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203293) in anhydrous DMSO is also available. |
| Catalogue Number | 203290 |
| Brand Family | Calbiochem® |
| Synonyms | 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide, Gö 6850, GF 109203X |
| Product Information | |
|---|---|
| CAS number | 133052-90-1 |
| ATP Competitive | Y |
| Form | Deep orange solid |
| Hill Formula | C₂₅H₂₄N₄O₂ |
| Chemical formula | C₂₅H₂₄N₄O₂ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Bisindolylmaleimide I, CAS 133052-90-1, is a cell-permeable, highly selective, reversible inhibitor of protein kinase C (IC50 = 10 nM). Acts on the ATP-binding site of PKC. |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information |
|---|
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Número de catálogo | GTIN |
| 203290-1MG | 04055977221121 |
| 203290-250UG | 07790788048327 |
Documentation
Bisindolylmaleimide I - CAS 133052-90-1 - Calbiochem MSDS
| Título |
|---|
Bisindolylmaleimide I - CAS 133052-90-1 - Calbiochem Certificados de análise
| Título | Número do lote |
|---|---|
| 203290 |
Referências
| Visão geral de referência |
|---|
| Hers, I., et al. 1999. FEBS Lett. 460, 433. Ku, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730. Gekeler, V., et al. 1996. Br. J. Cancer 74, 897. Kiss, Z., et al. 1995. Biochim. Biophys. Acta 1265, 93. Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771. |
Citações
| Título | |
|---|---|
|
|
| Ficha de dados | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|