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616370 Aprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem

Aprotinin, Bovine Lung, Crystalline, CAS 9087-70-1, is a competitive, reversible, heat- and acid-stable inhibitor of proteolytic and esterolytic activities.

Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: Pancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor

Primary Target: chymotrypsin
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CAS #
9087-70-1

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          Description
          OverviewA competitive and reversible inhibitor of esterases and proteases. Forms a tight complex with and blocks the active site of the enzymes. Inhibits a number of different proteases, including chymotrypsin, coagulation factors involved in the prephase of blood clotting, kallikrein (Kd = 1 x 10-7 M), plasmin (Kd = 2.3 x 10-10 M) , tissue and leukocytic proteinases, and trypsin (Kd = 5 x 10-14 M). Does not inhibit Factor Xa and thrombin. It is relatively acid- and heat-stable. Useful as a serine protease inhibitor during purification of proteins and in studies of zymogen activation systems. Reported to suppress virus HA cleavage and limit reproduction of human and avian influenza viruses with a single arginine in the HA cleavage site.
          Effectively inhibits target proteases at equimolar concentration.
          Note: 1 KIU = 0.025 antiplasmin units (APU) = 0.0016 trypsin inhibitor units (using porcine trypsin) = 0.0009756 trypsin inhibitor units (using bovine trypsin).
          Catalogue Number616370
          Brand Family Calbiochem®
          SynonymsPancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor
          References
          ReferencesZhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.
          Roberts, R.F., et al. 1998. Ann. Thorac. Surg. 66, 225.
          Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
          Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
          Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
          McKeehan, W.L., et al. 1986. J. Biol. Chem. 261, 5378.
          Fritz, H., and Wunderer, G. 1983. Arzneim. Forsch. 33, 479.
          Rijken, D.C., and Collen, D. 1981. J. Biol. Chem. 256, 7035.
          Kassell, B., et al. 1970. Methods Enzymol. 19, 845.
          Product Information
          CAS number9087-70-1
          Activity≥5500 KIU/mg dry weight
          Unit of DefinitionOne Kallikrein Inhibitory Unit (K.I.U.) is defined as the quantity of protease inhibitor that will inhibit two kallikrein units by 50% under optimal conditions. Note: 1 KIU = 0.025 antiplasmin units (APU) or 0.0031 trypsin inhibitor units.
          ATP CompetitiveN
          FormWhite to off-white crystalline solid
          Hygroscopic Hygroscopic
          PI10.5
          ReversibleY
          Quality LevelMQ200
          Applications
          Biological Information
          Primary Targetchymotrypsin
          Primary Target IC<sub>50</sub>Kd = 1 x 10-7 M, 2.3 x 10-10 M, 5 x 10-14 M, against kallikrein, plasmin, and trypsin, respectively
          Purity≥95% by gel filtration
          Physicochemical Information
          Cell permeableN
          Contaminantsendotoxin: ≤10 EU/mg
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSYN5080000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de catálogo GTIN
          616370-100MG 04055977262889
          616370-20MG 04055977262896

          Documentation

          Aprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem MSDS

          Título

          Ficha de Segurança de Produtos (MSDS) 

          Aprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem Certificados de análise

          TítuloNúmero do lote
          616370

          Referências

          Visão geral de referência
          Zhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.
          Roberts, R.F., et al. 1998. Ann. Thorac. Surg. 66, 225.
          Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
          Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
          Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
          McKeehan, W.L., et al. 1986. J. Biol. Chem. 261, 5378.
          Fritz, H., and Wunderer, G. 1983. Arzneim. Forsch. 33, 479.
          Rijken, D.C., and Collen, D. 1981. J. Biol. Chem. 256, 7035.
          Kassell, B., et al. 1970. Methods Enzymol. 19, 845.

          Brochura

          Título
          Bulk Product Guide

          Citações

          Título
        • Zhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.
          		•
          Ficha de dados

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-February-2012 RFH
          SynonymsPancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor
          DescriptionA competitive and reversible inhibitor of esterase and protease activity. Forms a tight complex with and blocks the active site of target enzymes. Inhibits a number of different proteases, including chymotrypsin, coagulation factors involved in the pre-phase of blood clotting, kallikrein (Kd = 1 X 10-7 M), plasmin (Kd = 2.3 X 10-10 M), tissue and leukocyte proteinases, and trypsin (Kd = 5 X 10-14 M). Does not inhibit Factor Xa or thrombin. Reported to be relatively acid and heat stable. Effectively inhibits target proteases at equimolar concentration. Useful as a serine proteinase inhibitor during purification of proteins and in studies of zymogen activation systems. Reported to suppress virus HA cleavage and limit reproduction of human and avian influenza viruses with a single arginine in the HA cleavage site.
          FormWhite to off-white crystalline solid
          CAS number9087-70-1
          RTECSYN5080000
          Purity≥95% by gel filtration
          Contaminantsendotoxin: ≤10 EU/mg
          Activity≥5500 KIU/mg dry weight
          Unit definitionOne Kallikrein Inhibitory Unit (K.I.U.) is defined as the quantity of protease inhibitor that will inhibit two kallikrein units by 50% under optimal conditions. Note: 1 KIU = 0.025 antiplasmin units (APU) or 0.0031 trypsin inhibitor units.
          SolubilityH₂O (10 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
          Toxicity Standard Handling
          Merck USA index14, 757
          ReferencesZhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.
          Roberts, R.F., et al. 1998. Ann. Thorac. Surg. 66, 225.
          Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
          Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
          Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
          McKeehan, W.L., et al. 1986. J. Biol. Chem. 261, 5378.
          Fritz, H., and Wunderer, G. 1983. Arzneim. Forsch. 33, 479.
          Rijken, D.C., and Collen, D. 1981. J. Biol. Chem. 256, 7035.
          Kassell, B., et al. 1970. Methods Enzymol. 19, 845.
          Citation
        • Zhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.
          		•