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05-636-AF488 Anti-phospho Histone H2A.X (Ser139), clone JBW301, Alexa Fluor® 488 Conjugate Antibody

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05-636-AF488
100 µL  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HICCMAlexaFluor®488Monoclonal Antibody
      Description
      Catalogue Number05-636-AF488
      DescriptionAnti-phospho Histone H2A.X (Ser139), clone JBW301, Alexa Fluor® 488 Conjugate Antibody
      Alternate Names
      • Histone H2AX
      • H2a/x
      • Histone H2A.X
      Background InformationHistone H2A.X is a variant of histone H2A, and is similarly associated with genomic DNA. However, histone is structurally different from other members of the H2A family in possessing a C-terminal tail that contains the Ser139 residue that is phosphorylated in response to breaks in double-stranded DNA. The phosphorylation of H2A.X is a rapid process that is mediated by ATM/ATR proteins.
      Product Information
      FormatAlexaFluor®488
      PresentationPurified mouse conjugate in buffer containing PBS, 15 mg/mL BSA, and 0.1% Sodium Azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-phospho Histone H2A.X (Ser139) antibody, clone JBW301, Alexa Fluor® 488 Conjugate is validated for use in ICC for the detection of phospho Histone H2A.X (Ser139).
      Key Applications
      • Immunocytochemistry
      Biological Information
      ImmunogenLinear peptide corresponding to phospho-Histone H2A.X (Ser139).
      CloneJBW301
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Vertebrates based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • H2AFX
      • H2AX
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight17 kDa calculated
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in untreated (negative control) and Staurosporin treated HeLa cells.

      Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected phospho-Histone H2A.X (Ser139) in Staurosporin treated HeLa cells, and not in untreated HeLa cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Global Trade Item Number
      Número de catálogo GTIN
      05-636-AF488 04053252971907