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07-1213 Anti-IP3 Receptor 1 Antibody

This Anti-IP3 Receptor 1 Antibody is validated for use in IH(P), WB for the detection of IP3 Receptor 1.

Anti-IP3 Receptor 1 Antibody: Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.
Research Category: Signaling Research Sub-Category: Lipid Signaling Gene Symbol: INSP3R1, IP3R, IP3R1, InsP3R1, Insp3r1, SCA15, SCA16 UniProt Number: Q14643
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07-1213
100 µL  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H, Ca, RIH(P), WBRbSerumPolyclonal Antibody
      Description
      Catalogue Number07-1213
      ReplacesAB9072
      DescriptionAnti-IP3 Receptor 1 Antibody
      Alternate Names
      • IP3 receptor isoform 1
      • Type 1 InsP3 receptor
      • Type 1 inositol 1,4,5-trisphosphate receptor
      • inositol 1,4,5-triphosphate receptor, type 1
      • spinocerebellar ataxia 15
      • spinocerebellar ataxia 16
      Background InformationIP3 Receptor 1 is an intracellular channel that when stimulated by inositol 1,4,5-triphosphate mediates the release of calcium from the endoplasmic reticulum. Defects within the gene ITPR1 cause a group of cerebellar disorders known as spinocerebellar ataxia type 15 (SCA15). This receptor is widely expressed in tissue.
      References
      Product Information
      FormatSerum
      HS Code3002 15 90
      Control
      • C2C12 cell lysates
      PresentationRabbit serum. Liquid
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-IP3 Receptor 1 Antibody is validated for use in IH(P), WB for the detection of IP3 Receptor 1.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:100 dilution of this antibody detected IP3 Receptor 1 in mouse cerebellum tissue.
      Biological Information
      ImmunogenSynthetic peptide from the N-terminal of human IP3 Receptor 1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThe antibody reacts with the 300 kDa IP3 Receptor 1 protein.
      Isotypemixed IgGs
      Species Reactivity
      • Mouse
      • Human
      • Canine
      • Rat
      Species Reactivity NoteProven to react with mouse and human. Expected to react with canine and rat based on sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • INSP3R1
      • IP3R
      • IP3R1
      • InsP3R1
      • Insp3r1
      • SCA15
      • SCA16
      Purification MethodUnpurified rabbit serum
      UniProt Number
      UniProt SummaryFUNCTION: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate.
      SUBUNIT STRUCTURE: Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Interacts with AHCYL1 By similarity. Interacts with MRVI1 and CABP1 (via N-terminus).
      SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Widely expressed.
      DOMAIN: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
      PTM: Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels By similarity.
      Phosphorylated on tyrosine residues.
      INVOLVEMENT IN DISEASE: Defects in ITPR1 are the cause of spinocerebellar ataxia type 15 (SCA15) (SCA15) [MIM:606658]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory.
      MISCELLANEOUS: Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor.
      SEQUENCE SIMILARITIES: Belongs to the InsP3 receptor family.
      Contains 5 MIR domains.
      Molecular WeightApprox. 300 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in C2C12 cell lysates.
      Western Blot Analysis: 1:500 dilution of this lot detected IP3 RECPT 1 on 10 ug of C2C12 lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 1 year date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      07-1213 04053252281846

      Documentation

      Anti-IP3 Receptor 1 Antibody MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Anti-IP3 Receptor 1 Antibody Certificados de análise

      TítuloNúmero do lote
      Anti- IP3 Receptor 1 - 2119010 2119010
      Anti- IP3 Receptor 1 - 2128259 2128259
      Anti- IP3 Receptor 1 - 1945620 1945620
      Anti- IP3 Receptor 1 - 2198975 2198975
      Anti- IP3 Receptor 1 - 2324677 2324677
      Anti- IP3 Receptor 1 - 3232423 3232423
      Anti- IP3 Receptor 1 - 3319800 3319800
      Anti- IP3 Receptor 1 - 3546915 3546915
      Anti- IP3 Receptor 1 - 3709632 3709632
      Anti- IP3 Receptor 1 - 3733813 3733813
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