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CBL517 Anti-CD28 Antibody, clone 15E8

This Anti-CD28 Antibody, clone 15E8 is validated for use in FC, FUNC for the detection of CD28.

Anti-CD28 Antibody, clone 15E8: Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: CD28, Tp44, TP44, MGC138290 UniProt Number: P10747
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CBL517
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, FUNCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL517
      ReplacesCBL517P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CD28 Antibody, clone 15E8
      Alternate Names
      • Tp44
      References
      Product Information
      FormatPurified
      HS Code3002 15 90
      PresentationPlease see lot specific datasheet for product formulation. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-CD28 Antibody, clone 15E8 is validated for use in FC, FUNC for the detection of CD28.
      Key Applications
      • Flow Cytometry
      • Affects Function
      Application NotesTo study the role of CD28 in T cell proliferation. The antibody will induce the proliferation of resting T lymphocytes.

      This antibody will act in cell stimulation studies where it has been suggested that measuring T cell function in HIV infected asymptomatic patients may be an early indicator of AIDS, independent of CD4 + cell counts

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenHuman T lymphocytes
      Clone15E8
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody reacts with the 44 kDa antigen found on a sub-population of T cells and activated B cells. These CD28+ CD8 cells are now known to be cytotoxic T cell precursors. The antibody does not react with B cells, granulocytes or monocytes. The ligand for CD28 is CD80 (B7) which is found on activated B cells suggesting a role for CD28 in T and B cell interaction

      FUSION PARTNER: SP2/0
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCD28 costimulation is essential for CD4 (MIM 186940)-positive T-cell proliferation, survival, interleukin-2 (IL2; MIM 147680) production, and T-helper type-2 (Th2) development.[supplied by OMIM]
      Gene Symbol
      • CD28
      • Tp44
      • TP44
      • MGC138290
      Non-Reactive Species
      • Canine
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P10747 # Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
      SIZE: 220 amino acids; 25066 Da
      SUBUNIT: Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Expressed in T-cells and plasma cells, but not in less mature B-cells.
      SIMILARITY: SwissProt: P10747 ## Contains 1 Ig-like V-type (immunoglobulin-like) domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C for up to one year.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      CBL517 04053252589904

      Documentation

      Anti-CD28 Antibody, clone 15E8 MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Anti-CD28 Antibody, clone 15E8 Certificados de análise

      TítuloNúmero do lote
      Anti-CD28, clone 15E8 2484244
      Anti-CD28, clone 15E8 - 2398899 2398899
      Anti-CD28, clone 15E8 - 2446857 2446857
      Anti-CD28, clone 15E8 - 2454700 2454700
      Anti-CD28, clone 15E8 - 2463637 2463637
      Anti-CD28, clone 15E8 - 2145952 2145952
      Anti-CD28, clone 15E8 - 3167053 3167053
      Anti-CD28, clone 15E8 - 3187447 3187447
      Anti-CD28, clone 15E8 - 3233125 3233125
      Anti-CD28, clone 15E8 - 3286048 3286048
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