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124005 Akt Inhibitor - Calbiochem

This Akt inhibitor is a cell-permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (IC50 of 5.0 µM).

Akt Inhibitor - Calbiochem: Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: 1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate

Primary Target: Akt
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124005
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Replacement Information

Tabela com principais espec.

Empirical Formula
C₃₀H₅₈O₁₀

Preço e Disponibilidade

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      Description
      OverviewA cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC50 of 5.0 µM). Moderately inhibits PI 3-K activity (IC50 = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC50 values in the 1 - 10 µM range.
      Catalogue Number124005
      Brand Family Calbiochem®
      Synonyms1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate
      References
      ReferencesHu, Y., et al. 2000 J. Med. Chem. 43, 3045.
      Product Information
      ATP CompetitiveY
      FormWhite to off-white solid
      Hill FormulaC₃₀H₅₈O₁₀
      Chemical formulaC₃₀H₅₈O₁₀
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationThis Akt inhibitor is a cell-permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (IC50 of 5.0 µM).
      Biological Information
      Primary TargetAkt
      Primary Target IC<sub>50</sub>5.0 µM for Akt (PKB)
      Purity≥98% by NMR
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      124005-1MG 07790788047979

      Documentation

      Akt Inhibitor - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      Akt Inhibitor - Calbiochem Certificados de análise

      TítuloNúmero do lote
      124005

      Referências

      Visão geral de referência
      Hu, Y., et al. 2000 J. Med. Chem. 43, 3045.

      Brochura

      Título
      Akt
      Biologics 31.1
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-June-2011 JSW
      Synonyms1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate
      DescriptionA cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC50 of 5.0 µM). Moderately inhibits PI 3-K activity (IC50 = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC50 values in the 1-10 µM range.
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₀H₅₈O₁₀
      Structure formulaStructure formula
      Purity≥98% by NMR
      SolubilityDMSO (200 mg/ml). Use anhydrous DMSO for reconstitution.
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.
      Toxicity Standard Handling
      ReferencesHu, Y., et al. 2000 J. Med. Chem. 43, 3045.