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101500 AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem

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CAS #Empirical Formula
30827-99-7C₈H₁₀FNO₂S · HCl

Preço e Disponibilidade

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101500-100MG
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      101500-1GM
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          Description
          OverviewSpecific, irreversible inhibitor of serine proteases. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). A β-secretase inhibitor that inhibits β-amyloid peptide (Aβ) production and enhances amyloid precursor protein (sAPPUα) secretion in several cell lines at millimolar concentrations. Use at the same molar concentrations (0.1-1.0 mM) as PMSF for most applications. Also available as a 50 mM solution in H2O (Cat. No. 508436).
          Catalogue Number101500
          Brand Family Calbiochem®
          Synonyms4-(2-Aminoethyl)benzenesulfonylfluoride, HCl
          Application Data
          References
          ReferencesCitron, M., et al. 1996. Neuron 17, 171.
          Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
          Mintz, G.R. 1993. BioPharm. 6, 34.
          Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
          Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
          Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
          Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.
          Product Information
          CAS number30827-99-7
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₈H₁₀FNO₂S · HCl
          Chemical formulaC₈H₁₀FNO₂S · HCl
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetchymotrypsin
          Purity>97% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 2 months at 4°C. Slight hydrolysis occurs at alkaline pH (8-9).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de catálogo GTIN
          101500-100MG 04055977226317
          101500-1GM 04055977226300

          Documentation

          AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem MSDS

          Título

          Ficha de Segurança de Produtos (MSDS) 

          AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem Certificados de análise

          TítuloNúmero do lote
          101500

          Referências

          Visão geral de referência
          Citron, M., et al. 1996. Neuron 17, 171.
          Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
          Mintz, G.R. 1993. BioPharm. 6, 34.
          Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
          Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
          Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
          Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.

          Brochura

          Título
          Bulk Product Guide

          Citações

          Título
        • Catherine Mee-Hie Cho, Ashok Mulchandani and Wilfred Chen. (2006) Functional analysis of organophosphorus hydrolase variants with high degradation activity towards organophosphate pesticides. Protein Engineering Design and Selection 19, 99-105.
        • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
        • Sharon Yagur-Kroll and Orna Amster-Choder. (2005) Dynamic membrane topology of the E. coli -glucoside transporter β-glucosidase transporter BglF. Journal of Biological Chemistry 280, 19306-19318.
        • Valerie A. Fadok, et al. (2001) Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases. Journal of Immunology 166, 6847-6854.
        • Ficha de dados

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-September-2013 JSW
          Synonyms4-(2-Aminoethyl)benzenesulfonylfluoride, HCl
          Application Data
          DescriptionSpecific irreversible inhibitor of serine proteases. Reacts covalently with a serine at the active site. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). Used at the same molar concentration (0.1-1.0 mM) as PMSF for most applications. Exhibits low inhibitory activity towards proteinase K.
          FormWhite to off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number30827-99-7
          Chemical formulaC₈H₁₀FNO₂S · HCl
          Structure formulaStructure formula
          Purity>97% by HPLC
          SolubilityH₂O (25 mg/ml)
          Storage Protect from moisture
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 2 months at 4°C. Slight hydrolysis occurs at alkaline pH (8-9).
          Toxicity Standard Handling
          ReferencesCitron, M., et al. 1996. Neuron 17, 171.
          Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
          Mintz, G.R. 1993. BioPharm. 6, 34.
          Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
          Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
          Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
          Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.
          Citation
        • Catherine Mee-Hie Cho, Ashok Mulchandani and Wilfred Chen. (2006) Functional analysis of organophosphorus hydrolase variants with high degradation activity towards organophosphate pesticides. Protein Engineering Design and Selection 19, 99-105.
        • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
        • Sharon Yagur-Kroll and Orna Amster-Choder. (2005) Dynamic membrane topology of the E. coli -glucoside transporter β-glucosidase transporter BglF. Journal of Biological Chemistry 280, 19306-19318.
        • Valerie A. Fadok, et al. (2001) Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases. Journal of Immunology 166, 6847-6854.
        • Produtos e aplicações relacionadas

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          Categorias

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors