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100105 A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem

A mobile ion-carrier that forms stable complexes with divalent cations.

Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: Calcimycin

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Tabela com principais espec.

CAS #Empirical Formula
52665-69-7C₂₉H₃₇N₃O₆

Preço e Disponibilidade

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      Description
      OverviewA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
      Catalogue Number100105
      Brand Family Calbiochem®
      SynonymsCalcimycin
      References
      ReferencesCaron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
      Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
      Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
      Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
      Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.
      Product Information
      CAS number52665-69-7
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₉H₃₇N₃O₆
      Chemical formulaC₂₉H₃₇N₃O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMitochondrial ATPase
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDM4676000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      100105-5MG 04055977226249

      Documentation

      A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      100105

      Referências

      Visão geral de referência
      Caron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
      Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
      Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
      Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
      Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

      Brochura

      Título
      Caspases and other Apoptosis Related Tools Brochure
      Tools and Tips for Analyzing Apoptosis
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      SynonymsCalcimycin
      DescriptionA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
      FormWhite solid
      CAS number52665-69-7
      RTECSDM4676000
      Chemical formulaC₂₉H₃₇N₃O₆
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO or Methanol. For use in aqueous systems, preparation of a 100 mM stock in DMSO is recommended. Microliter amounts of this solution can then be added to H₂O with rapid mixing (e.g. 10 µl into 5 ml of H₂O). In aqueous systems, the ionophore aggregates over time.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 1639
      ReferencesCaron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
      Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
      Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
      Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
      Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

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      Categorias

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