Millipore Sigma Vibrant Logo

393204 4-Hydroxynonenal - CAS 75899-68-2 - Calbiochem

4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.

Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: HNE, 4-Hydroxy-2-nonenal

Primary Target: Na+, K+-ATPase activity
View Products on Sigmaaldrich.com
393204
Ver preços e disponibilidade

Panorama geral

Replacement Information

Tabela com principais espec.

CAS #Empirical Formula
75899-68-2C₉H₁₆O₂

Preço e Disponibilidade

Número de catálogo DisponibilidadeEmbalagem Qtde/Emb. Preço Quantidade
393204-1MG
Verificando a disponibilidade...
—
Disponibilidade limitada Disponibilidade limitada
Insira quantidade 
Descontinuado
Quantidades limitadas disponíveis
Disponibilidade a ser confirmada
    Restante: será informado
      Restante: será informado
      Vai informar
      Contatar o serviço de atendimento ao cliente
      Contact Customer Service

      		 Frasco de vidro 1 mg
      Recuperando preço...
      O preço não pôde ser recuperado
      Quantidade mínima necessária para ser múltipla de
      Maximum Quantity is
      Após finalização do pedido Mais informações
      Você salvou ()
       
      —
      Solicitar preço
      		 —
      Description
      OverviewA major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages and in PC12 cells. An inhibitor of state 3 respiration at micromolar levels. Causes a transient increase in cytosolic Ca2+ and irreversibly inhibits Na+, K+-ATPase activity (IC50 = 120 µM). Acts as a reversible inhibitor of c-Jun N-terminal kinase (JNK).
      Catalogue Number393204
      Brand Family Calbiochem®
      SynonymsHNE, 4-Hydroxy-2-nonenal
      References
      ReferencesSoh, Y., et al. 2000. Mol. Pharmacol. 58, 535.
      Carini, R., et al. 1996. Biochem. Biophys. Res. Commun. 218, 772.
      Li, L., et al. 1996. Toxicol. Appl. Pharmacol. 139, 135.
      Siems, W.G., et al. 1996. Free Radic. Res. 20, 215.
      Ullrich, O., et al. 1996. Free Radic. Res. 24, 421.
      van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
      Esterbauer, H., et al. 1991. Free Radic. Biol. Med. 11, 81.
      Product Information
      CAS number75899-68-2
      ATP CompetitiveN
      FormLiquid
      FormulationSupplied at 10 mg/ml in ethanol
      Hill FormulaC₉H₁₆O₂
      Chemical formulaC₉H₁₆O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNa+, K+-ATPase activity
      Primary Target IC<sub>50</sub>120 µM against Na+, K+-ATPase activity
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSRA8510000
      Safety Information
      R PhraseR: 11

      Highly flammable.
      S PhraseS: 7-16

      Keep container tightly closed.
      Keep away from sources of ignition - No Smoking.
      Product Usage Statements
      Storage and Shipping Information
      Toxicity Flammable
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      393204-1MG 04055977212471

      Documentation

      4-Hydroxynonenal - CAS 75899-68-2 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      4-Hydroxynonenal - CAS 75899-68-2 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      393204

      Referências

      Visão geral de referência
      Soh, Y., et al. 2000. Mol. Pharmacol. 58, 535.
      Carini, R., et al. 1996. Biochem. Biophys. Res. Commun. 218, 772.
      Li, L., et al. 1996. Toxicol. Appl. Pharmacol. 139, 135.
      Siems, W.G., et al. 1996. Free Radic. Res. 20, 215.
      Ullrich, O., et al. 1996. Free Radic. Res. 24, 421.
      van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
      Esterbauer, H., et al. 1991. Free Radic. Biol. Med. 11, 81.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-July-2008 RFH
      SynonymsHNE, 4-Hydroxy-2-nonenal
      DescriptionA major aldehydic product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages. An inhibitor of State 3 respiration at micromolar levels that causes a transient increase in cytosolic Ca2+. Irreversibly inhibits Na+-K+-ATPase activity (IC50 = 120 µM).
      FormLiquid
      FormulationSupplied at 10 mg/ml in ethanol
      CAS number75899-68-2
      RTECSRA8510000
      Chemical formulaC₉H₁₆O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityEthanol (10 mg/ml)
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Flammable
      ReferencesSoh, Y., et al. 2000. Mol. Pharmacol. 58, 535.
      Carini, R., et al. 1996. Biochem. Biophys. Res. Commun. 218, 772.
      Li, L., et al. 1996. Toxicol. Appl. Pharmacol. 139, 135.
      Siems, W.G., et al. 1996. Free Radic. Res. 20, 215.
      Ullrich, O., et al. 1996. Free Radic. Res. 24, 421.
      van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
      Esterbauer, H., et al. 1991. Free Radic. Biol. Med. 11, 81.