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410957 3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem

3-Isobutyl-1-methylxanthine, CAS 28822-58-4, is a cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM).

Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: IBMX

Primary Target: cAMP and cGMP phosphodiesterases
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410957
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Tabela com principais espec.

CAS #Empirical Formula
28822-58-4C₁₀H₁₄N₄O₂

Preço e Disponibilidade

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      Description
      OverviewA cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNF-α expression in adipocyte precursor cells.
      Catalogue Number410957
      Brand Family Calbiochem®
      SynonymsIBMX
      References
      ReferencesHube, F., et al. 1999. Horm. Metab. Res. 31, 359.
      Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373.
      Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
      Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
      Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
      Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
      Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.
      Product Information
      CAS number28822-58-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₀H₁₄N₄O₂
      Chemical formulaC₁₀H₁₄N₄O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Application3-Isobutyl-1-methylxanthine, CAS 28822-58-4, is a cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM).
      Biological Information
      Primary TargetcAMP and cGMP phosphodiesterases
      Primary Target IC<sub>50</sub>2-50 µM against cAMP and cGMP phosphodiesterases
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSZD8500000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in ethanol or methanol, refrigerate (4°C). Following reconstitution in DMSO, aliquot and freeze (-20°C). Ethanol/methanol and DMSO stock solutions are stable for up to 6 months at 4°C or -20°C, respectively.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      410957-250MG 04055977211146

      Documentation

      3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem Certificados de análise

      TítuloNúmero do lote
      410957

      Referências

      Visão geral de referência
      Hube, F., et al. 1999. Horm. Metab. Res. 31, 359.
      Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373.
      Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
      Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
      Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
      Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
      Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.

      Brochura

      Título
      Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-July-2013 JSW
      SynonymsIBMX
      DescriptionA non-specific, cell-permeable inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNFα expression in adipocyte precursor cells.
      FormWhite solid
      CAS number28822-58-4
      RTECSZD8500000
      Chemical formulaC₁₀H₁₄N₄O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mM), Ethanol (10 mg/ml), or Methanol (50 mg/ml). Heating may be required to achieve complete solubilization.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in ethanol or methanol, refrigerate (4°C). Following reconstitution in DMSO, aliquot and freeze (-20°C). Ethanol/methanol and DMSO stock solutions are stable for up to 6 months at 4°C or -20°C, respectively.
      Toxicity Standard Handling
      ReferencesHube, F., et al. 1999. Horm. Metab. Res. 31, 359.
      Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373.
      Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
      Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
      Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
      Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
      Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.