Millipore Sigma Vibrant Logo

565767 α-Secretase Substrate II, Fluorogenic - Calbiochem

An internally quenched fluorogenic peptide substrate containing the α-secretase cleavage site of β-Amyloid Precursor Protein (APP).

Ficha de dados de segurança do material (FDSM) ou ficha de segurança do material (FSM), certificado de análise (CA) e certificado de qualidade (CQ), dossiês e outros documentos disponíveis.

Sinônimos: Ac-RE(EDANS)-VHHQKLVF-K(DABCYL)-R-OH

View Products on Sigmaaldrich.com
565767
Ver preços e disponibilidade

Panorama geral

Replacement Information

Preço e Disponibilidade

Número de catálogo DisponibilidadeEmbalagem Qtde/Emb. Preço Quantidade
565767-1MG
Verificando a disponibilidade...
—
Disponibilidade limitada Disponibilidade limitada
Insira quantidade 
Descontinuado
Quantidades limitadas disponíveis
Disponibilidade a ser confirmada
    Restante: será informado
      Restante: será informado
      Vai informar
      Contatar o serviço de atendimento ao cliente
      Contact Customer Service

      		 Ampola plástica 1 mg
      Recuperando preço...
      O preço não pôde ser recuperado
      Quantidade mínima necessária para ser múltipla de
      Maximum Quantity is
      Após finalização do pedido Mais informações
      Você salvou ()
       
      —
      Solicitar preço
      		 —
      Description
      OverviewAn internally quenched fluorogenic peptide substrate containing the α-secretase cleavage site of β-Amyloid Precursor Protein (APP). Shown to be a substrate for yapsin 2, a glycosyl-phosphatidylinositol-linked yeast aspartyl protease (Vmax/Km = 0.031 min-1). The cleavage is shown to occur at the Lys-Leu bond.
      Catalogue Number565767
      Brand Family Calbiochem®
      SynonymsAc-RE(EDANS)-VHHQKLVF-K(DABCYL)-R-OH
      References
      ReferencesKomano, H., et al. 1999. J. Biol. Chem. 274, 24431.
      Komano, H., et al. 1998. J. Biol. Chem. 273, 31648.
      Product Information
      ATP CompetitiveN
      FormRed solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₀₀H₁₄₄N₃₀O₂₀S
      Chemical formulaC₁₀₀H₁₄₄N₃₀O₂₀S
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSubstrate containing the α-secretase cleavage site of β-Amyloid Precursor Protein (APP)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Emission max.
      Excitation max.
      Peptide SequenceAc-Arg-Glu(EDANS)-Val-His-His-Gln-Lys-Leu-Val-Phe-Lys(DABCYL)-Arg-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de catálogo GTIN
      565767-1MG 04055977267754

      Documentation

      α-Secretase Substrate II, Fluorogenic - Calbiochem MSDS

      Título

      Ficha de Segurança de Produtos (MSDS) 

      α-Secretase Substrate II, Fluorogenic - Calbiochem Certificados de análise

      TítuloNúmero do lote
      565767

      Referências

      Visão geral de referência
      Komano, H., et al. 1999. J. Biol. Chem. 274, 24431.
      Komano, H., et al. 1998. J. Biol. Chem. 273, 31648.
      Ficha de dados

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-September-2008 RFH
      SynonymsAc-RE(EDANS)-VHHQKLVF-K(DABCYL)-R-OH
      DescriptionAn internally quenched fluorogenic peptide substrate that contains the α-secretase cleavage site of β-amyloid precursor protein (APP). Shown to be an effective substrate for yapsin-2, a glycosyl-phosphatidylinositol-linked aspartyl protease found in yeast (Vmax/Km = 0.031 min-1). The cleavage has been shown to occur at the Lys-Leu bond. Excitation max: ~340 nm; emission max: ~490 nm.
      FormRed solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₀₀H₁₄₄N₃₀O₂₀S
      Peptide SequenceAc-Arg-Glu(EDANS)-Val-His-His-Gln-Lys-Leu-Val-Phe-Lys(DABCYL)-Arg-OH
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKomano, H., et al. 1999. J. Biol. Chem. 274, 24431.
      Komano, H., et al. 1998. J. Biol. Chem. 273, 31648.