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Syringe Filters

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HPLC-certified Millex® hydrophilic
PTFE syringe filters
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Merck:/Freestyle/BI-Bioscience/Chromatography-Sample-Prep/chromatography-sample-prep-images/Blue-Samplicity.jpgProducts for Sample Preparation

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There’s Only One Millex® Syringe Filter.

Improve signal-to-noise ratios, maintain clean baselines and maximize instrument uptime with trusted Millex® syringe filters. With low extractables and low analyte-binding membranes, Millex® syringe filters are the most convenient, highest-quality syringe filters for sensitive instrumental analyses, including gas, liquid, and ion chromatography. Wide chemical compatibility enables their use with virtually any sample composition.

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Syringe filters: How Quality Could Make or Break Your HPLC

This short animation explains how your syringe filter might be putting your HPLC at risk. Some syringe filters exhibit unpredictable loss of membrane integrity, allowing particles to pass through the filter. These particles could contaminate and/or clog the expensive HPLC column.

Compare Performance to Other Syringe Filters:
(Click each chart to enlarge.)

Superior device integrity for clean baselines and maximum instrument uptime:
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Comparison of particle retention frequency of various syringe filters.
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In principle, 100% of filtration membranes should retain particles. To test this hypothesis, various syringe microfilters (pore sizes either 0.2 or 0.45 µm) were tested for air particle retention using a Lasair® II particle measurement system.
Higher sample recovery prevents loss of precious samples and ensures accurate results:
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Lower hold-up volume prevents loss of precious samples. Graph shows comparison of recovery from 0.2 µm pore size PVDF membrane syringe filters.


Particles trapped on a PVDF membrane filter that could have clogged a UHPLC column.
Particles trapped on a 0.2 μm PVDF membrane filter after filtration of 2 L of 50 mM sodium bicarbonate buffer. If the buffer were not filtered before running through the column, these particles could contaminate and clog the expensive UHPLC column.

Protect Your Expensive System with an Inexpensive Filter.

Membrane filtration removes contaminating particles from samples, solvents, and mobile phases, increasing column life, minimizing backpressure, and preventing system failure.

Filtration through 0.2 µm hydrophilic PTFE Millex® filters prevents backpressure buildup on a UHPLC system.
Water and acetonitrile were passed through polypropylene or PTFE syringe filters (as indicated in legend), then used 1:1 (v/v) to prepare the mobile phase for UHPLC. The system was run at 0.25 mL/min for 600 min with backpressure recorded every 50 min. DP represents total change in backpressure after 600 min.