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676481 VEGFR Tyrosine Kinase Inhibitor II - CAS 269390-69-4 - Calbiochem

The VEGFR Tyrosine Kinase Inhibitor II, also referenced under CAS 269390-69-4, controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide, VEGF Receptor Tyrosine Kinase Inhibitor II, VEGFR2 Kinase Inhibitor XVII, VEGFR1 Kinase Inhibitor III

Primary Target: Kinase activities of KDR, Flt-1 and c-Kit
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676481
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
269390-69-4C₁₉H₁₆ClN₃O

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676481-5MG
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      Description
      OverviewA pyridinyl-anthranilamide compound that displays both antiangiogenic and antitumor properties. A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the kinase activities of KDR, Flt-1 and c-Kit (IC50 = 20 nM, 180 nM and 240 nM, respectively), and minimally inhibit c-Src and EGF-R activities (IC50 = 7 µM and 7.3 µM). Further, inactive towards the inhibition of CDK-1, c-Met, IGF-1R and PKA (IC50 > 10 µM).
      Catalogue Number676481
      Brand Family Calbiochem®
      SynonymsN-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide, VEGF Receptor Tyrosine Kinase Inhibitor II, VEGFR2 Kinase Inhibitor XVII, VEGFR1 Kinase Inhibitor III
      References
      ReferencesFuret, P., et al. 2003. Bioorg. Med. Chem. Lett. 13, 2967.
      Product Information
      CAS number269390-69-4
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₉H₁₆ClN₃O
      Chemical formulaC₁₉H₁₆ClN₃O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetKinase activities of KDR, Flt-1 and c-Kit
      Primary Target IC<sub>50</sub>20 nM, 180 nM and 240 nM against kinase activities of KDR, Flt-1 and c-Kit, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      676481-5MG 04055977183610

      Documentation

      VEGFR Tyrosine Kinase Inhibitor II - CAS 269390-69-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      VEGFR Tyrosine Kinase Inhibitor II - CAS 269390-69-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      676481

      References

      Reference overview
      Furet, P., et al. 2003. Bioorg. Med. Chem. Lett. 13, 2967.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-January-2010 RFH
      SynonymsN-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide, VEGF Receptor Tyrosine Kinase Inhibitor II, VEGFR2 Kinase Inhibitor XVII, VEGFR1 Kinase Inhibitor III
      DescriptionA potent, cell-permeable, reversible, and ATP-competitive inhibitor of the kinase activities of KDR, Flt-1 and c-Kit (IC50 = 20 nM, 180 nM and 240 nM, respectively), and minimally inhibit c-Src and EGF-R activities (IC50 = 7.0 µM and 7.3 µM). Also displays antiangiogenic and antitumor properties. Does not inhibit the activities of CDK-1, c-Met, IGF-1R or PKA (IC50 > 10 µM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number269390-69-4
      Chemical formulaC₁₉H₁₆ClN₃O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml) or methanol
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesFuret, P., et al. 2003. Bioorg. Med. Chem. Lett. 13, 2967.